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  1. ...Whole-genome Trees Based on the Occurrence of Folds and Orthologs: Implications for Comparing Genomes on Different Levels Jimmy Lin 1 and Mark Gerstein 1 , 2 1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 USA...
  2. ...in proteomes is evolutionarily conserved and capable of preserving an accurate record of genomic history. Here we use a census of protein architecture in 185 genomes that have been fully sequenced to generate genome-based phylogenies that describe the evolution of the protein world at fold (F) and fold...
  3. ..., Illinois 61801, USA Abstract Protein structural diversity encompasses a finite set of architectural designs. Embedded in these topologies are evolutionary histories that we here uncover using cladistic principles and measurements of protein-fold usage and sharing. The reconstructed phylogenies...
  4. ...structural folds ( Doolittle 1995 ; Vogel et al. 2004 ; Orengo and Thornton 2005 ; Fong et al. 2007 ; Han et al. 2007 ). Some of these domain combinations are stable during evolution whereas others are more labile. Accordingly, domains differ in their tendency to appear in variable multidomain contexts...
  5. ...names and protein names, and one may search for a protein of interest using the find feature of a WWW browser. One may also select a region from the physical map of the , or use the listing of BLAST sequence neighbors grouped by taxonomic superkingdom. These routes also lead to a listing of any...
  6. .... The structural domains used in this work also have advantages when compared with structural information that has been used to infer phylogenies in previous studies ( Wolf et al. 1999 ; Lin and Gerstein 2000 ). These studies were based on the “fold” level of structural classification, which correspond to clusters...
  7. .... The known PMK enzymes encoded by metazoan s are unrelated to the galactokinase family, and their evolutionary origin was unclear. We found that metazoan PMK are distantly related to nucleoside monophosphate kinases found in all superkingdoms of life and in viruses. The database searches revealed moderate...
  8. ...structural and functional features are common and which confer species specificity. In this paper, we present an integrated analysis of the proteomes of human and 13 other species considering the folds of globular domains, the presence of transmembrane proteins, and the extent to which the proteomes can...
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