Searching journal content for articles similar to Wei et al. 32 (11-12): 1981.

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Research: Distinct classes of lamina-associated domains are defined by differential patterns of repressive histone methylation
- Caden J. Martin,
- Elizabeth A. Oser,
- Prabakaran Nagarajan,
- Liudmila V. Popova,
- Benjamin D. Sunkel,
- Benjamin Z. Stanton,
- and Mark R. Parthun
Genome Res. September 2025 35: 1959-1974; Published in Advance August 5, 2025, doi:10.1101/gr.280380.124
...at Nationwide Children's Hospital, Columbus, Ohio 43205, USA Corresponding author: Parthun.1@osu.eduAbstractA large fraction of the interacts with the nuclear periphery through lamina-associated domains (LADs), repressive regions which play an important role in organization and gene regulation across...
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Research: Mapping multitissue regulatory variants reveals a liver-centric coexpression network associated with duck egg-laying performance
- Yang Xi,
- Jingjing Qi,
- Zhao Yang,
- Yutian Zeng,
- Huicong Zhang,
- Qiuyu Tao,
- Mengru Xu,
- Anqi Huang,
- Shenqiang Hu,
- Chunchun Han,
- Lili Bai,
- Jiwei Hu,
- Jiwen Wang,
- Liang Li,
- Lingzhao Fang,
- and Hehe Liu
Genome Res. October 2025 35: 2211-2225; Published in Advance September 10, 2025, doi:10.1101/gr.280345.124
..., nonalcoholic fatty liver disease has been identified as a risk factor for polycystic ovary syndrome, highlighting a potential link between metabolic dysfunction and reproductive disorders (Liu et al. 2023). Similarly, single-cell transcriptomic analyses in ducks has revealed that the major cellular...
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Research: Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits
- Kevin W. Currin,
- Hannah J. Perrin,
- Gautam K. Pandey,
- Abdalla A. Alkhawaja,
- Swarooparani Vadlamudi,
- Annie E. Musser,
- Amy S. Etheridge,
- K. Alaine Broadaway,
- Jonathan D. Rosen,
- Arushi Varshney,
- Amarjit S. Chaudhry,
- Paul J. Gallins,
- Fred A. Wright,
- Yi-hui Zhou,
- Stephen C.J. Parker,
- Laura M. Raffield,
- Erin G. Schuetz,
- Federico Innocenti,
- and Karen L. Mohlke
Genome Res. July 2025 35: 1485-1502; Published in Advance May 20, 2025, doi:10.1101/gr.279741.124
...these coordinately regulated element sets are formed, and identifying driver elements will help fine-map causal elements and variants at colocalized GWAS loci (van Mierlo et al. 2023).The liver influences many human traits and diseases through its role in protein synthesis, lipid and glucose metabolism...
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Research: Convergent relaxation of molecular constraint in herbivores reveals the changing role of liver and kidney functions across mammalian diets
- Matthew D. Pollard,
- Wynn K. Meyer,
- and Emily E. Puckett
Genome Res. December 2024 34: 2176-2189; Published in Advance November 22, 2024, doi:10.1101/gr.278930.124
...as lineages became more herbivorous. Liver and kidney functions show similar patterns of constraint with dietary change. Our results indicate that these functions are important for the consumption of animal matter and become less important with the evolution of increasing herbivory. So, genes expressed...
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Research: A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha
- Kevin Gesson,
- Philipp Rescheneder,
- Michael P. Skoruppa,
- Arndt von Haeseler,
- Thomas Dechat,
- and Roland Foisner
Genome Res. April 2016 26: 462-473; Published in Advance January 21, 2016, doi:10.1101/gr.196220.115
..., Domrachev M, Lash AE. 2002. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30: 207–210. Gesson K, Vidak S, Foisner R. 2014. Lamina-associated polypeptide (LAP)2α and nucleoplasmic lamins in adult stem cell regulation and disease. Semin Cell Dev Biol...
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Resource: Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson's disease
- Kangli Wang,
- Weikun Xia,
- Yingli Gu,
- Songpeng Zu,
- Qian Yang,
- Maria Luisa Amaral,
- Yaozhi Wang,
- Allen Wang,
- Xiang-Dong Fu,
- William C. Mobley,
- and Bing Ren
Genome Res. March 4, 2026 ; Published in Advance March 4, 2026, doi:10.1101/gr.281113.125
...Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson’s disease Kangli Wang,1 Weikun Xia,1 Yingli Gu,1 Songpeng Zu,1 Qian Yang,2 Maria Luisa Amaral,1 Yaozhi Wang,1 Allen Wang,2 Xiang-Dong Fu,3 William C. Mobley,4 and Bing Ren1...
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Resource: Global compositional and functional states of the human gut microbiome in health and disease
- Sunjae Lee,
- Theo Portlock,
- Emmanuelle Le Chatelier,
- Fernando Garcia-Guevara,
- Frederick Clasen,
- Florian Plaza Oñate,
- Nicolas Pons,
- Neelu Begum,
- Azadeh Harzandi,
- Ceri Proffitt,
- Dorines Rosario,
- Stefania Vaga,
- Junseok Park,
- Kalle von Feilitzen,
- Fredric Johansson,
- Cheng Zhang,
- Lindsey A. Edwards,
- Vincent Lombard,
- Franck Gauthier,
- Claire J. Steves,
- David Gomez-Cabrero,
- Bernard Henrissat,
- Doheon Lee,
- Lars Engstrand,
- Debbie L. Shawcross,
- Gordon Proctor,
- Mathieu Almeida,
- Jens Nielsen,
- Adil Mardinoglu,
- David L. Moyes,
- Stanislav Dusko Ehrlich,
- Mathias Uhlen,
- and Saeed Shoaie
Genome Res. June 2024 34: 967-978; Published in Advance July 22, 2024, doi:10.1101/gr.278637.123
..., (GDM) gestational diabetes mellitus, (T1D) type 1 diabetes, (T2D) type 2 diabetes, (LC) liver cirrhosis, (NAFLD) nonalcoholic fatty acid liver, (UC) ulcerative colitis, (CD) Crohn's disease, (BD) Behçet's disease, (RA) rheumatoid arthritis, (SPA) ankylosing spondylitis, (ME/CFS) myalgic...
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Research: Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments
- Michael I. Robson,
- Jose I. de las Heras,
- Rafal Czapiewski,
- Aishwarya Sivakumar,
- Alastair R.W. Kerr,
- and Eric C. Schirmer
Genome Res. July 2017 27: 1126-1138; Published in Advance April 19, 2017, doi:10.1101/gr.212308.116
...concomitantly with expression changes during hematopoiesis and immune activation. Studies have focused either on lamina-associated domains (LADs) or on topologically associated domains (TADs), defined by preferential local chromatin interactions, and chromosome compartments, defined as higher-order interactions...
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Research: Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo
- Hee-Woong Lim,
- N. Henriette Uhlenhaut,
- Alexander Rauch,
- Juliane Weiner,
- Sabine Hübner,
- Norbert Hübner,
- Kyoung-Jae Won,
- Mitchell A. Lazar,
- Jan Tuckermann,
- and David J. Steger
Genome Res. June 2015 25: 836-844; Published in Advance May 8, 2015, doi:10.1101/gr.188581.114
...(Laudadio et al. 2012) and FOXA2 (Li et al. 2012) in liver to examine the GR ChIP-exo reads at common sites that are also bound by ONECUT1 or FOXA2. Opposite-stranded peaks flank the ONECUT1 motif with the same spacing found by ONECUT1 ChIP-exo (Wang et al. 2014), while an asymmetric profile of positioned...
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Resource: Cell type–specific gene regulatory atlas prioritizes drug targets and repurposable medicines in Alzheimer's disease
- Yunxiao Ren,
- Ming Hu,
- Yang E. Li,
- Andrew A. Pieper,
- Jeffrey Cummings,
- and Feixiong Cheng
Genome Res. March 2026 36: 645-659; Published in Advance January 21, 2026, doi:10.1101/gr.280436.125
...Cell type–specific gene regulatory atlas prioritizes drug targets and repurposable medicines in Alzheimer's disease Yunxiao Ren1,2, Ming Hu3,4, Yang E. Li5, Andrew A. Pieper6,7,8,9,10,11, Jeffrey Cummings12 and Feixiong Cheng1,2,4,13 1Cleveland Clinic Genome Center, Cleveland Clinic Research...
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