Searching journal content for articles similar to Weckselblatt et al. 25 (7): 937.

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  1. Research: Multisite long-read sequencing reveals the early contributions of somatic structural variations to HBV-related hepatocellular carcinoma tumorigenesis
    • Tianfu Zeng,
    • Haotian Liao,
    • Lin Xia,
    • Siyao You,
    • Yanqun Huang,
    • Jiaxun Zhang,
    • Yahui Liu,
    • Xuyan Liu,
    • and Dan Xie
    Genome Res. April 2025 35: 671-685; Published in Advance March 4, 2025, doi:10.1101/gr.279617.124
    ...practice to predict therapeutic response, highlighting the incomplete understanding of the mutational landscape of HCC.Structural variants (SVs) are large genomic alterations (>50 bp), distinct from small variants like SNVs and short insertions and deletions (indels), as they often arise from different...
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  2. Research: Functional genomic analysis of chromosomal aberrations in a compendium of 8000 cancer genomes
    • Tae-Min Kim,
    • Ruibin Xi,
    • Lovelace J. Luquette,
    • Richard W. Park,
    • Mark D. Johnson,
    • and Peter J. Park
    Genome Res. February 2013 23: 217-227; Published in Advance November 6, 2012, doi:10.1101/gr.140301.112
    ...is known to give rise to the TMPRSS2-ERG gene fusion in prostate cancer (Kumar-Sinha et al. 2008), and the observed pattern is consistent with the ‘‘fusion breakpoint principle’’ of unbalanced translocation events (Wang et al. 2009). The co-occurrence of intragenic deletion breakpoints of ERG and TMPRSS2...
  3. Resource: Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements
    • Tatiana Maroilley,
    • Stephane Flibotte,
    • Francesca Jean,
    • Victoria Rodrigues Alves Barbosa,
    • Andrew Galbraith,
    • Afiya Razia Chida,
    • Filip Cotra,
    • Xiao Li,
    • Larisa Oncea,
    • Mark Edgley,
    • Don Moerman,
    • and Maja Tarailo-Graovac
    Genome Res. January 2023 33: 154-167; Published in Advance December 5, 2022, doi:10.1101/gr.276988.122
    ...balanced with little to no change in copy number and arise from nonhomologous end joining restitching after chromosome pulverization. Chromoplexy involves several chained translocations, whereas chromothripsis is mainly characterized by inversions and rearrangements in often one or occasionally a few...
  4. Research: Rearrangements of viral and human genomes at human papillomavirus integration events and their allele-specific impacts on cancer genome regulation
    • Vanessa L. Porter,
    • Michelle Ng,
    • Kieran O'Neill,
    • Signe MacLennan,
    • Richard D. Corbett,
    • Luka Culibrk,
    • Zeid Hamadeh,
    • Marissa Iden,
    • Rachel Schmidt,
    • Shirng-Wern Tsaih,
    • Carolyn Nakisige,
    • Martin Origa,
    • Jackson Orem,
    • Glenn Chang,
    • Jeremy Fan,
    • Ka Ming Nip,
    • Vahid Akbari,
    • Simon K. Chan,
    • James Hopkins,
    • Richard A. Moore,
    • Eric Chuah,
    • Karen L. Mungall,
    • Andrew J. Mungall,
    • Inanc Birol,
    • Steven J.M. Jones,
    • Janet S. Rader,
    • and Marco A. Marra
    Genome Res. April 2025 35: 653-670; Published in Advance December 5, 2024, doi:10.1101/gr.279041.124
    ...(lication)-like, translocation, multi-breakpoint, or repeat region integrations. Integrations involving amplified HPV–human concatemers, particularly multi-breakpoint events, frequently harbor heterogeneous forms and copy numbers of the viral . Transcriptionally active integrants are characterized by unmethylated regions...
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