Searching journal content for articles similar to Warnefors et al. 27 (12): 1961.

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  1. Research: Dosage-sensitive functions in embryonic development drove the survival of genes on sex-specific chromosomes in snakes, birds, and mammals
    • Daniel W. Bellott and
    • David C. Page
    Genome Res. February 2021 31: 198-210; Published in Advance January 21, 2021, doi:10.1101/gr.268516.120
    ...of duplication (Fig. 2C). MicroRNAs (miRNAs) are short, noncoding RNAs that fine-tune gene dosage by pairing to the 3′ untranslated region and lowering target mRNA levels (Bartel 2009). Conserved targeting by miRNAs is a feature of genes sensitive to changes in gene dosage, particularly to overexpression (Naqvi...
  2. Research: Conserved microRNA targeting reveals preexisting gene dosage sensitivities that shaped amniote sex chromosome evolution
    • Sahin Naqvi,
    • Daniel W. Bellott,
    • Kathy S. Lin,
    • and David C. Page
    Genome Res. April 2018 28: 474-483; Published in Advance February 15, 2018, doi:10.1101/gr.230433.117
    ...Chromosome inactivation (XCI) in females, but some Y-linked genes were retained during the course of sex chromosome evolution, and many X-linked genes did not become subject to XCI. We reconstructed gene-by-gene dosage sensitivities on the ancestral autosomes through phylogenetic analysis of microRNA (mi...
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  3. Research: Birth and expression evolution of mammalian microRNA genes
    • Julien Meunier,
    • Frédéric Lemoine,
    • Magali Soumillon,
    • Angélica Liechti,
    • Manuela Weier,
    • Katerina Guschanski,
    • Haiyang Hu,
    • Philipp Khaitovich,
    • and Henrik Kaessmann
    Genome Res. January 2013 23: 34-45; Published in Advance October 3, 2012, doi:10.1101/gr.140269.112
    ...in evolutionary biology. In addition to protein sequence changes, gene expression alterations due to regulatory mutations are thought to underlie many or even most phenotypic innovations (King and Wilson 1975). MicroRNAs (miRNAs) are short (approximately 22 nucleotides) noncoding RNA molecules that bind...
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  4. Research: Quantitative analysis of Y-Chromosome gene expression across 36 human tissues
    • Alexander K. Godfrey,
    • Sahin Naqvi,
    • Lukáš Chmátal,
    • Joel M. Chick,
    • Richard N. Mitchell,
    • Steven P. Gygi,
    • Helen Skaletsky,
    • and David C. Page
    Genome Res. June 2020 30: 860-873; Published in Advance May 27, 2020, doi:10.1101/gr.261248.120
    ...by microRNAs (miRNAs), small regulatory RNAs that act as sequence-specific repressors of gene expression (Bartel 2018). A miRNA might specifically target EIF1AX, limiting its expression level in these tissues. When we searched the 3′ untranslated region (3′ UTR) of EIF1AX (Methods), the miRNA target site...
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