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Research: Spatial organization of chromosomes leads to heterogeneous chromatin motion and drives the liquid- or gel-like dynamical behavior of chromatin
- Hossein Salari,
- Marco Di Stefano,
- and Daniel Jost
Genome Res. January 2022 32: 28-43; Published in Advance December 28, 2021, doi:10.1101/gr.275827.121
...the “dynamic” nature of chromatin folding and its importance on key biological functions (Bystricky 2015; Tortora et al. 2020; Shaban et al. 2020a). Chromatin mobility has been proposed to impact the dynamics of promoter–enhancer interactions and thus regulates transcriptional bursting (Bartman et al. 2016...
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Research: Systems analysis reveals complex biological processes during virus infection fate decisions
- Jordi Argilaguet,
- Mireia Pedragosa,
- Anna Esteve-Codina,
- Graciela Riera,
- Enric Vidal,
- Cristina Peligero-Cruz,
- Valentina Casella,
- David Andreu,
- Tsuneyasu Kaisho,
- Gennady Bocharov,
- Burkhard Ludewig,
- Simon Heath,
- and Andreas Meyerhans
Genome Res. June 2019 29: 907-919; Published in Advance May 28, 2019, doi:10.1101/gr.241372.118
...). They show a “two-peak” behavior with an expression peak at d5 and a second up-regulation from d7 to d9 PI. The second peak of expression of Xcl1 was verified by qPCR using additional infected mice (Supplemental Fig. S8A). In contrast to chronic infection, Xcl1 showed only a single early peak of expression...

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