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  1. ...expression. These regions with dynamic H3K27ac exhibited VEGFA-stimulated transcriptional activity in both luciferase assays and in HUVEC gene expression profiles, and EP300 inhibition blockedVEGFA-induced changes inH3K27ac and gene expression. Thus, our study indicates that the epi is an integral...
  2. ...with Mbp levels in neighboring cells. A possible interpretation is that cells expressing Flt1 accumulate in the spatial vicinity of cells which lack Mbp. This would be in line with the observation that VEGFA (which is recognized by FLT1) promotes the migration of oligodendrocyte precursor cells (OPCs...
  3. ...dynamics during ZGA are highly divergent among species. Thus, it is necessary to investigate the epigenetic reprogramming specificities that are orchestrated with ZGA in different vertebrates.Pig (Sus scrofa domesticus) is widely regarded as an important agricultural resource and alternative model...
  4. ...individual cells by integrating co-expression data with transcription factor motif enrichment analysis, generating a “regulon,” which refers to an expressed transcription factor and all of its co-expressed target genes. We obtained the predicted regulon activities using AUCell, which ranks targets of each...
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