Searching journal content for articles similar to Wang et al. 22 (7): 1316.

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  1. Method: Precision genome engineering with programmable DNA-nicking enzymes
    • Eunji Kim,
    • Sojung Kim,
    • Duk Hyoung Kim,
    • Beom-Soon Choi,
    • Ik-Young Choi,
    • and Jin-Soo Kim
    Genome Res. July 2012 22: 1327-1333; Published in Advance April 20, 2012, doi:10.1101/gr.138792.112
    ...– 5736. Wang J, Friedman G, Doyon Y, Wang NS, Li CJ, Miller JC, Hua KL, Yan JJ, Babiarz JE, Gregory PD, et al. 2012. Targeted gene addition to a predetermined site in the human using a ZFN-based nicking enzyme. Genome Res (this issue) doi: 10.1101/gr.122879.111. Zhang F, Cong L, Lodato S, Kosuri S...
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  2. Perspective: Enabling functional genomics with genome engineering
    • Isaac B. Hilton and
    • Charles A. Gersbach
    Genome Res. October 2015 25: 1442-1455; doi:10.1101/gr.190124.115
    ...to gene editing in eukaryotes, but have been less widely adopted in the context of functional genomics due to the complexity involved in engineering meganucleases targeted to new sequences. Editing sequences with programmable nucleases Gene targeting based on homologous recombination can introduce...
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  3. Perspective: What does our genome encode?
    • John A. Stamatoyannopoulos
    Genome Res. September 2012 22: 1602-1611; doi:10.1101/gr.146506.112
    ...-occupied sites (Sanyal et al. 2012). Composite interaction technologies developed within ENCODE such as ChIA-PET—essentially a combination of ChIP-seq with a chromosome conformation capture assay—are further illuminating the 3D connectivity of human Stamatoyannopoulos 1604 Genome Research www..org genes with one...
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  4. Method: Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
    • Seung Woo Cho,
    • Sojung Kim,
    • Yongsub Kim,
    • Jiyeon Kweon,
    • Heon Seok Kim,
    • Sangsu Bae,
    • and Jin-Soo Kim
    Genome Res. January 2014 24: 132-141; Published in Advance November 19, 2013, doi:10.1101/gr.162339.113
    ...immune system known as CRISPR/Cas, enable targeted genome engineering in cells and organisms. RGENs are ribonucleoproteins that consist of guide RNA and Cas9, a protein component originated from Streptococcus pyogenes . These enzymes cleave chromosomal DNA, whose sequence is complementary, to guide RNA...
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