..., despite lacking TSDs.The third ICC tumor-specific L1 insertion (Fig. 4C; Supplemental Fig. S8C), found in patient ICC.75,
bore 16-bp TSDs, occurred at a near-perfect L1 endonuclease cleavage motif (5′-TT/AGAA-3′), and incorporated a short (18-bp) 3′ transduction flanked by 13- and 28-bp poly(A) tracts...