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Viñuela et al. 20 (7): 929
.
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139
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Research
:
Genome-wide patterns of selection–drift variation strongly associate with organismal traits across the green plant lineage
Kavitha Uthanumallian
,
Andrea Del Cortona
,
Susana M. Coelho
,
Olivier De Clerck
,
Sebastian Duchene
,
and
Heroen Verbruggen
Genome Res.
August 2024
34
:
1130
-
1139
;
Published in Advance
August 29, 2024
,
doi:
10.1101/gr.279002.124
...
Genome-wide
patterns of selection–drift variation strongly associate with organismal traits across the green plant lineage Kavitha Uthanumallian1, Andrea Del Cortona2, Susana M. Coelho3, Olivier De Clerck2, Sebastian Duchene4,5 and Heroen Verbruggen1,6 1Melbourne Integrative Genomics, School of Bio...
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Research
:
Genome-wide profiling reveals functional interplay of DNA sequence composition, transcriptional activity, and nucleosome positioning in driving DNA supercoiling and helix destabilization in
C. elegans
Kristina Krassovsky
,
Rajarshi P. Ghosh
,
and
Barbara J. Meyer
Genome Res.
July 2021
31
:
1187
-
1202
;
Published in Advance
June 24, 2021
,
doi:
10.1101/gr.270082.120
...overwind or underwind DNA, creating DNA supercoils (Kouzine and Levens 2007). Supercoils can, in turn, induce formation of single-stranded DNA (ssDNA, hereafter SS DNA) or other non-B DNA structures.
Genome-wide
mapping of alternative DNA structures in cell lines and computational predictions in s suggested...
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Research
:
A low-abundance class of Dicer-dependent siRNAs produced from a variety of features in
C. elegans
Thiago L. Knittel
,
Brooke E. Montgomery
,
Alex J. Tate
,
Ennis W. Deihl
,
Anastasia S. Nawrocki
,
Frederic J. Hoerndli
,
and
Taiowa A. Montgomery
Genome Res.
December 2024
34
:
2203
-
2216
;
Published in Advance
December 2, 2024
,
doi:
10.1101/gr.279083.124
...). Nonetheless, even at low abundance, they could have important roles in
gene
regulation and thus their identification would be an important step toward a more complete understanding of the small RNA landscape of C.
elegans
. In this study, our aim was to identity and characterize these siRNAs in the context...
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Research
:
Natural variation in
C. elegans
short tandem repeats
Gaotian Zhang
,
Ye Wang
,
and
Erik C. Andersen
Genome Res.
October 2022
32
:
1852
-
1861
;
Published in Advance
October 4, 2022
,
doi:
10.1101/gr.277067.122
...across wild C.
elegans
strains.Results
Genome-wide
profiling of STR variation in C.
elegans
To investigate the natural variation of C.
elegans
STRs, we first identified 31,991 reference STRs in the C.
elegans
reference (Table 1; Supplemental Table S1). These STRs comprise motif lengths of 1–6 bp...
Abstract
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Research
:
A genome-wide transcriptome and translatome analysis of
Arabidopsis
transposons identifies a unique and conserved genome expression strategy for
Ty1/Copia
retroelements
Stefan Oberlin
,
Alexis Sarazin
,
Clément Chevalier
,
Olivier Voinnet
,
and
Arturo Marí-Ordóñez
Genome Res.
September 2017
27
:
1549
-
1562
;
Published in Advance
August 7, 2017
,
doi:
10.1101/gr.220723.117
...and transcriptionally active transposons in A. thaliana is illustrated by our comprehensive analysis of the cotranscriptional and translational features of Ty1/Copia elements, a family of young and active retroelements in plant s, and how such features impact their biology.
Genome-wide
transcript profiling revealed...
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Method
:
Accurate typing of short tandem repeats from genome-wide sequencing data and its applications
Arkarachai Fungtammasan
,
Guruprasad Ananda
,
Suzanne E. Hile
,
Marcia Shu-Wei Su
,
Chen Sun
,
Robert Harris
,
Paul Medvedev
,
Kristin Eckert
,
and
Kateryna D. Makova
Genome Res.
May 2015
25
:
736
-
749
;
Published in Advance
March 30, 2015
,
doi:
10.1101/gr.185892.114
...STRs with consecutive repeat numbers. Applying our model and pipeline to Illumina sequencing data with 100-bp reads, we could confidently
genotype
several disease-related long trinucleotide STRs. Utilizing this pipeline, for the first time we determined the
genome-wide
STR germline mutation rate from...
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Method
:
Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome
Jakob Skou Pedersen
,
Eivind Valen
,
Amhed M. Vargas Velazquez
,
Brian J. Parker
,
Morten Rasmussen
,
Stinus Lindgreen
,
Berit Lilje
,
Desmond J. Tobin
,
Theresa K. Kelly
,
Søren Vang
,
Robin Andersson
,
Peter A. Jones
,
Cindi A. Hoover
,
Alexei Tikhonov
,
Egor Prokhortchouk
,
Edward M. Rubin
,
Albin Sandelin
,
M. Thomas P. Gilbert
,
Anders Krogh
,
Eske Willerslev
,
and
Ludovic Orlando
Genome Res.
March 2014
24
:
454
-
466
;
Published in Advance
December 3, 2013
,
doi:
10.1101/gr.163592.113
...
Genome-wide
nucleosome map and cytosine methylation levels of an ancient human genome Jakob Skou Pedersen 1 , 14 , 15 , Eivind Valen 2 , 3 , 14 , Amhed M. Vargas Velazquez 4 , Brian J. Parker 3 , Morten Rasmussen 4 , 5 , Stinus...
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Method
:
Characterization of meiotic recombination intermediates through gene knockouts in founder hybrid mice
Benjamin Davies
,
Gang Zhang
,
Daniela Moralli
,
Samy Alghadban
,
Daniel Biggs
,
Chris Preece
,
Peter Donnelly
,
and
Anjali Gupta Hinch
Genome Res.
November 2023
33
:
2018
-
2027
;
Published in Advance
November 17, 2023
,
doi:
10.1101/gr.278024.123
...phenotype (Fig. 2B). Furthermore, no sperm could be isolated from their caudal epididymides (Fig. 2C).
Genome-wide
maps of RAD51 and RPA binding in Dmc1−/− mouse testesUsing this pipeline of optimized mutagenesis via CRISPR-Cas9 electroporation, followed by verification of absence of DMC1 at the protein...
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Resource
:
A large-scale zebrafish gene knockout resource for the genome-wide study of gene function
Gaurav K. Varshney
,
Jing Lu
,
Derek E. Gildea
,
Haigen Huang
,
Wuhong Pei
,
Zhongan Yang
,
Sunny C. Huang
,
David Schoenfeld
,
Nam H. Pho
,
David Casero
,
Takashi Hirase
,
Deborah Mosbrook-Davis
,
Suiyuan Zhang
,
Li-En Jao
,
Bo Zhang
,
Ian G. Woods
,
Steven Zimmerman
,
Alexander F. Schier
,
Tyra G. Wolfsberg
,
Matteo Pellegrini
,
Shawn M. Burgess
,
and
Shuo Lin
Genome Res.
April 2013
23
:
727
-
735
;
Published in Advance
February 4, 2013
,
doi:
10.1101/gr.151464.112
...A large-scale zebrafish
gene
knockout resource for the
genome-wide
study of
gene
function Gaurav K. Varshney 1 , 8 , Jing Lu 2 , 3 , 8 , Derek E. Gildea 4 , Haigen Huang 3 , Wuhong Pei 1 , Zhongan Yang 3 , Sunny C. Huang...
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Research
:
Pangenome analysis reveals families of ubiquitin-ligase adaptors as key genomic divergence drivers that lead to hybrid incompatibility
Dongying Xie
,
Pohao Ye
,
Yiming Ma
,
and
Zhongying Zhao
Genome Res.
March 2026
36
:
506
-
521
;
Published in Advance
February 17, 2026
,
doi:
10.1101/gr.280885.125
...nematode (C.
elegans
, C. remanei, and Caenorhabditis brenneri; see Methods), only 5% (294 out of 5426) and 2.5% (60 out of 2393) of C. nigoni–specific and C. briggsae–specific dispensable
genes
, respectively, are shared with these outgroups (Fig. 3B; Supplemental Table S4). This suggests that these
gene
...
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Single-cell gene signature scoring
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