Searching journal content for articles similar to Ulianov et al. 26 (1): 70.

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  1. ...architectural features; these include A/B compartments, topologically associating domains (TADs), and chromatin loops (Lieberman-Aiden et al. 2009; Dixon et al. 2012; Nora et al. 2012; Sexton et al. 2012; Rao et al. 2014). Improvements in 3C sequencing technologies resulted in improved sequencing depth...
  2. ...(Pol II) -wide. These approaches provide a high-resolution view of transcription initiation, pausing, and elongation, enabling rapid detection of transcriptional changes following TF perturbation.Other methods survey Pol II–associated chromatin-bound RNAs, such as chromatin-associated RNA-seq (Chr...
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  3. ...chromatin domains, often referred to as topological associating domains (TADs), as fundamental units of three-dimensional (3D) organization (Szabo et al. 2018). Such domains are closely linked to important DNA-dependent and cellular processes, such as DNA replication (Pope et al. 2014), transcription...
  4. ...modifications, and other aspects of chromatin remains mysterious.3D chromatin domains3D chromatin research often examines topologically associated domains (TADs), which manifest as triangles of high signal intensity in chromatin contact maps, indicative of interactions among loci in close linear proximity...
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  5. ....zabet@qmul.ac.ukAbstractThe DNA in many organisms, including humans, is shown to be organized in topologically associating domains (TADs). In Drosophila, several architectural proteins are enriched at TAD borders, but it is still unclear whether these proteins play a functional role in the formation and maintenance of TADs. Here...
  6. ...@cse.cuhk.edu.hk, xin.gao@kaust.edu.saAbstractChromatin loop identification plays an important role in molecular biology and 3D genomics research, as it constitutes a fundamental process in transcription and gene regulation. Such precise chromatin structures can be identified across -wide interaction matrices via Hi...
  7. ...in every chromosome and are clustered throughout the cell cycle. In this study, the -wide occupancy of the replication initiation protein Orc4 reveals its abundance at all centromeres in C. albicans. Orc4 is associated with four different DNA sequence motifs, one of which coincides with tRNA genes (t...
  8. ...–J) Predicted domain boundaries fall within regions of heterochromatin. Domain boundaries are associated with reduced chromatin accessibility (F), H3K4me1 (G), and sequence conservation (H) and with elevated repeat element density (I) and H3K27me3 (J).We next explored intra-chromosomal interactions in our Hi...
  9. ...Cancer Research Center, Seattle, Washington 98109, USA ↵6 These authors contributed equally to this work. Corresponding author: dnotani@ncbs.res.inAbstractVertebrate s are partitioned into chromatin domains or topologically associating domains (TADs), which are typically bound by head-to-head pairs...
  10. ...species and cell types revealed that interphase chromosomes are partitioned at different scales (Rowley and Corces 2018): from topologically associating domains (TADs) (Dixon et al. 2012) at a few hundreds of kilobase pairs, to the euchromatic “A” and heterochromatic “B” compartments at megabase pair...
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