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  1. ...evolution result in complex human architecture. Genome Res. 14 : 2209 – 2220 . ↵ Tuzun E. , Bailey J.A. , Eichler E.E. ( 2004 ) Recent segmental duplications in the working draft assembly of the brown Norway rat. Genome Res. 14 : 493 – 506 . ↵ Tuzun E. , Sharp A.J. , Bailey J.A. , Kaul R. , Morrison V...
  2. ...3 , doi: 10.1371/journal.pgen.0030003 . ↵ Guryev, V. , Saar, K. , Adamovic, T. , Verheul, M. , van Heesch, S.A. , Cook, S. , Pravenec, M. , Aitman, T. , Jacob, H. , Shull, J.D. , et al. ( 2008 ) Distribution and functional impact of DNA copy number variation in the rat . Nat. Genet. 40 : 538 – 545...
  3. .... The working draft nature of the mouse , we believe, precludes such a precise estimate. Our combined analyses, however, suggest a range from 1.7% to 2.0% (for duplications ≥90% and ≥10 kb). This estimate is lower than what has recently been predicted for the rat (2.9%; Tuzun et al. 2004 ). The percentage...
  4. ...( Waterston et al. 2002 ), 2.92% for the 2.75 Gb of the Brown Norway rat ( Rattus norvegicus, v. 3.1) ( Rew 2004 ), and 5% for the 3 Gb of the human ( Bailey et al. 2001 , 2002 ; Lander et al. 2001 ; Venter et al. 2001 ). According to HR models, genomic features such as size and density in repeated sequences...
  5. ...platform. We identified 3.6 million high-quality single nucleotide polymorphisms (SNPs) between the SHR/OlaIpcv and Brown Norway (BN) reference genome, with a high rate of validation (sensitivity 96.3%–98.0% and specificity 99%–100%). We also identified 343,243 short indels between the SHR...
  6. ...proportions of rodent s, 2.92% in the rat ( Tuzun et al. 2004 ) and 1%-1.2% in the mouse ( Cheung et al. 2003 ). These studies have found that both intrachromosomal and interchromosomal or transchromosomal segmental duplications are mosaics of sequences duplicated from within one chromosome or nonhomologous...
  7. .... Genetic Mapping of New Microsatellite Loci A single large intercross derived from the Goto-Kakizaki (GK) and Brown Norway (BN) rats (n=139) was used to integrate new DnGot microsatellite markers showing allele variations between the two parental strains into existing linkage maps (Gauguier et al. 1996...
  8. ...of a blood pressure QTL on chromosome 16 of Dahl rats. Mamm. Genome 13 : 153 -156. ↵ Rat Genome Sequencing Project Consortium. 2004 . Genome sequence of the Brown Norway Rat yields insights into mammalian evolution. Nature (in press). ↵ Rodriguez-Tome, P. and Lijnzaad, P. 2001 . RHdb: The Radiation Hybrid...
  9. ...., Horsnell, T., and Coulson, A. 1988 . Software for mapping by fingerprinting techniques. Comput. Appl. Biosci. 4 : 125 -132. ↵ Tuzun, E., Bailey, J.A., and Eichler, E.E. 2004 . Recent segmental duplications in the working draft assembly of the brown Norway rat. Genome Res. (this issue). ↵ Waterston, R...
  10. ...) draft sequence (haplotype b; NT_039650). RT1 vs. HLA, comparison of 3.8-Mb RT1 sequence to HLA (NT007592; segment 20-25 Mb). Class I α1- and α3-domain homologies were identified by rat RT1-Au gene exons 2 and 4, respectively (from U38972). Analysis was performed using PipMaker. Colors within “heat map...
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