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REVIEW: Defensins and the dynamic genome: What we can learn from structural variation at human chromosome band 8p23.1
- Edward J. Hollox,
- John C.K. Barber,
- Anthony J. Brookes,
- and John A.L. Armour
Genome Res. November 2008 18: 1686-1697; doi:10.1101/gr.080945.108
...-defensin family, generating a distinct beta-defensin repertoire in the rat and mouse ( Morrison et al. 2003 ). The story is more complex than this may suggest. Despite evidence for duplication and pseudogenization in the rodents, evidence from primates and other mammalian groups suggests conservation of synteny...
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LETTER: Human Paralogs of KIAA0187 Were Created through Independent Pericentromeric-Directed and Chromosome-Specific Duplication Mechanisms
- Moira Crosier,
- Luigi Viggiano,
- Jane Guy,
- Doriana Misceo,
- Robert Stones,
- Wenbin Wei,
- Tom Hearn,
- Mario Ventura,
- Nicoletta Archidiacono,
- Mariano Rocchi,
- and Michael S. Jackson
Genome Res. January 1, 2002 12: 67-80; doi:10.1101/gr.213702
...that shares 40% identity to the Saccharomyces cerevisiae open reading frame (ORF) YPL217c at the protein level. It also shares significant identity along its entire length to mouse, rat, and nematode expressed sequence tags (ESTs; http://www.ncbi.nlm.nih.gov/UniGene/ ), consistent with functional conservation...

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