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  1. ...S2, S3). Eight of 11 genes that we found to escape X inactivation in mouse also escape in human (i.e., are expressed from at least one out of nine hybrids that retain the human inactive X) (Carrel and Willard 2005), suggesting that escape from X inactivation is partially conserved (Table 1...
  2. ...–HUWE1 region close to the end of the X chromosome in two marsupials led us to investigate whether the entire end of the marsupial X was conserved. Examination of the Ensembl v50 (July 2008) opossum assembly showed that the 2Mb region (71.6–73.6 Mb) with orthology to human Xp11, including the GPR173...
  3. ...19: 185–193. Brown CJ, Miller AP, Carrel L, Rupert JL, Davies KE, Willard HF. 1995. The DXS423E gene in Xp11.21 escapes X chromosome inactivation. Hum Mol Genet 4: 251–255. Carrel L, Willard HF. 2005. X-inactivation profile reveals extensive variability in X-linked gene expression in females...
  4. ...studies. Nat Rev Genet 8: 424–436. Takai D, Jones PA. 2003. The CpG island searcher: A new WWW resource. In Silico Biol 3: 235–240. Tsuchiya KD, Greally JM, Yi Y, Noel KP, Truong JP, Disteche CM. 2004. Comparative sequence and x-inactivation analyses of a domain of escape in human Xp11.2 and the conserved...
  5. ...a preponderance of large IRs that contain testes genes. However, the analysis must be revisited as the mouse sequence and assembly are improved. IRF analyses of the current and future assemblies of mouse will be included in the IRDB. Analysis of IR Structure in Human Chromosome Xp11.22 Similarity dot...
  6. ...embryos (cf. Fig. 4D and J, stars). KDM6A has been identified as a histone H3 K27 demethylase involved in epigenetic regulation of gene expression (Lee et al. 2007).Kdm6a also escapes X inactivation in both themouse and human (Greenfield et al. 1998). Expression of Ccdc160 in mutant embryos was first...
  7. ...that the replication domains correspond to chromosomal domains separated by boundary elements. Results Replication timing analyses of 1% using synchronized HeLa cells HeLa cells were synchronized at G1/S by thymidine-aphidicolin block. After release from the block, cells were pulsed with bromodeoxyuridine (Brd...
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