Searching journal content for articles similar to Toropainen et al. 32 (3): 409.

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  1. Method: Predicting genotype-specific gene regulatory networks
    • Deborah Weighill,
    • Marouen Ben Guebila,
    • Kimberly Glass,
    • John Quackenbush,
    • and John Platig
    Genome Res. March 2022 32: 524-533; Published in Advance February 22, 2022, doi:10.1101/gr.275107.120
    ...influences phenotype. For many traits, especially those related to human disease, this connection is not straightforward. The vast majority of phenotype-associated genetic variants are noncoding and have small effect sizes (Hall et al. 2016; Gallagher and Chen-Plotkin 2018), and a recent analysis found...
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  2. Review: Contrasting genetic architectures in different mouse reference populations used for studying complex traits
    • David A. Buchner and
    • Joseph H. Nadeau
    Genome Res. June 2015 25: 775-791; Published in Advance May 7, 2015, doi:10.1101/gr.187450.114
    ...). Tek expression was decreased in Ebola susceptible mice relative to Ebola resistant mice and was therefore hypothesized to influence Ebola susceptibility by regulating vascular integrity (Rasmussen et al. 2014). OS mice were used to fine-map a QTL for anxiety that led to the identification that Rgs2...
  3. Research: Variation in histone configurations correlates with gene expression across nine inbred strains of mice
    • Anna L Tyler,
    • Catrina Spruce,
    • Romy Kursawe,
    • Annat Haber,
    • Robyn L Ball,
    • Wendy A Pitman,
    • Alexander D Fine,
    • Narayanan Raghupathy,
    • Michael Walker,
    • Vivek M Philip,
    • Christopher L Baker,
    • J. Matthew Mahoney,
    • Gary A. Churchill,
    • Jennifer J Trowbridge,
    • Michael L Stitzel,
    • Kenneth Paigen,
    • Petko M Petkov,
    • and Gregory W Carter
    Genome Res. May 22, 2023 gr.277467.122; Published in Advance May 22, 2023, doi:10.1101/gr.277467.122
    ...). The resulting p-value distributions of each genomic feature suggested256 that each imputed feature was significantly associated with gene expression in the DO beyond the257 effects of the imputation alone (Supp. Fig. S6).258 We then tested the association between each imputed chromatin state, SNP, or CpG site...
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