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Torarinsson et al. 16 (7): 885
.
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62
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Research
:
Pangenome analysis reveals families of ubiquitin-ligase adaptors as key genomic divergence drivers that lead to hybrid incompatibility
Dongying Xie
,
Pohao Ye
,
Yiming Ma
,
and
Zhongying Zhao
Genome Res.
March 2026
36
:
506
-
521
;
Published in Advance
February 17, 2026
,
doi:
10.1101/gr.280885.125
...is primarily driven by differences in
unalignable
regions
We next investigated the sequence divergences underpinning the larger sizes of C. nigoni strains relative to C. briggsae strains. To this end, we leveraged the
genomic
variation detection tool SyRI (Goel et al. 2019), which systematically identifies...
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:
Genetic features and genomic targets of human KRAB-zinc finger proteins
Jonas de Tribolet-Hardy
,
Christian W. Thorball
,
Romain Forey
,
Evarist Planet
,
Julien Duc
,
Alexandre Coudray
,
Bara Khubieh
,
Sandra Offner
,
Cyril Pulver
,
Jacques Fellay
,
Michael Imbeault
,
Priscilla Turelli
,
and
Didier Trono
Genome Res.
August 2023
33
:
1409
-
1423
;
Published in Advance
September 20, 2023
,
doi:
10.1101/gr.277722.123
...significantly bound SVAs, and 11 were rather found at DNA transposons. The remaining 71 KZFPs mapped to a mixture of low complexity or simple repeats, satellite DNAs and t
RNAs
. For 24, no particular class of
genomic
entity could be singled out perhaps due in part to difficulties in sequences alignment, notably...
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:
Dissection of thousands of cell type-specific enhancers identifies dinucleotide repeat motifs as general enhancer features
J. Omar Yáñez-Cuna
,
Cosmas D. Arnold
,
Gerald Stampfel
,
Łukasz M. Boryń
,
Daniel Gerlach
,
Martina Rath
,
and
Alexander Stark
Genome Res.
July 2014
24
:
1147
-
1156
;
Published in Advance
April 8, 2014
,
doi:
10.1101/gr.169243.113
...groups was reflected by the expression levels of the neighboring genes asmeasuredby
RNA
-seq (Fig. 1C). For example, genes next to S2-specific enhancers were specifically expressed in S2 cells but not in BG3 cells or OSCs, and the equivalent was true for BG3- or OSC-specific enhancers. Genes next...
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Method
:
Alignment of single-cell RNA-seq samples without overcorrection using kernel density matching
Mengjie Chen
,
Qi Zhan
,
Zepeng Mu
,
Lili Wang
,
Zhaohui Zheng
,
Jinlin Miao
,
Ping Zhu
,
and
Yang I. Li
Genome Res.
April 2021
31
:
698
-
712
;
Published in Advance
March 19, 2021
,
doi:
10.1101/gr.261115.120
...al. 2014), and cellular response to stress and stimulation (Shalek et al. 2014; Keren-Shaul et al. 2017; Golumbeanu et al. 2018). Gene expression levels in tens of
thousands
of single cells are now routinely measured in a single sc
RNA
-seq experiment (Macosko et al. 2015), and more sc
RNA
-seq data sets...
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:
The identification and functional annotation of RNA structures conserved in vertebrates
Stefan E. Seemann
,
Aashiq H. Mirza
,
Claus Hansen
,
Claus H. Bang-Berthelsen
,
Christian Garde
,
Mikkel Christensen-Dalsgaard
,
Elfar Torarinsson
,
Zizhen Yao
,
Christopher T. Workman
,
Flemming Pociot
,
Henrik Nielsen
,
Niels Tommerup
,
Walter L. Ruzzo
,
and
Jan Gorodkin
Genome Res.
August 2017
27
:
1371
-
1383
;
Published in Advance
May 9, 2017
,
doi:
10.1101/gr.208652.116
...functional role. We computationally screened vertebrate s for conserved
RNA
structures (CRSs), leveraging structure-based, rather than sequence-based, alignments. After careful correction for sequence identity and GC content, we predict ∼516,000 human
genomic
regions
containing
CRSs. We find...
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LETTER
:
Comparative genomics beyond sequence-based alignments: RNA structures in the ENCODE regions
Elfar Torarinsson
,
Zizhen Yao
,
Eric D. Wiklund
,
Jesper B. Bramsen
,
Claus Hansen
,
Jørgen Kjems
,
Niels Tommerup
,
Walter L. Ruzzo
,
and
Jan Gorodkin
Genome Res.
February 2008
18
:
242
-
251
;
Published in Advance
December 20, 2007
,
doi:
10.1101/gr.6887408
...Comparative
genomics
beyond sequence-based alignments:
RNA
structures in the ENCODE
regions
Elfar Torarinsson 1 , 2 , Zizhen Yao 3 , Eric D. Wiklund 4 , Jesper B. Bramsen 4 , Claus Hansen 5 , Jørgen Kjems 4 , Niels Tommerup...
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:
Promoter-distal RNA polymerase II binding discriminates active from inactive CCAAT/ enhancer-binding protein beta binding sites
Daniel Savic
,
Brian S. Roberts
,
Julia B. Carleton
,
E. Christopher Partridge
,
Michael A. White
,
Barak A. Cohen
,
Gregory M. Cooper
,
Jason Gertz
,
and
Richard M. Myers
Genome Res.
December 2015
25
:
1791
-
1800
;
Published in Advance
October 20, 2015
,
doi:
10.1101/gr.191593.115
...
genomic
features that accurately discriminate between active and inactive TF binding events remain ambiguous. Recent studies have identified promoter-distal
RNA
polymerase II (RNAP2) binding at enhancer elements, suggesting that these interactions may serve as a marker for active regulatory sequences...
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LETTER
:
Structured RNAs in the ENCODE selected regions of the human genome
Stefan Washietl
,
Jakob S. Pedersen
,
Jan O. Korbel
,
Claudia Stocsits
,
Andreas R. Gruber
,
Jörg Hackermüller
,
Jana Hertel
,
Manja Lindemeyer
,
Kristin Reiche
,
Andrea Tanzer
,
Catherine Ucla
,
Carine Wyss
,
Stylianos E. Antonarakis
,
France Denoeud
,
Julien Lagarde
,
Jorg Drenkow
,
Philipp Kapranov
,
Thomas R. Gingeras
,
Roderic Guigó
,
Michael Snyder
,
Mark B. Gerstein
,
Alexandre Reymond
,
Ivo L. Hofacker
,
and
Peter F. Stadler
Genome Res.
June 2007
17
:
852
-
864
;
doi:
10.1101/gr.5650707
...Structured
RNAs
in the ENCODE selected
regions
of the human
genome
Stefan Washietl 1 , 14 , Jakob S. Pedersen 2 , Jan O. Korbel 3 , 4 , Claudia Stocsits 5 , Andreas R. Gruber 1 , Jörg Hackermüller 6 , Jana Hertel 5...
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:
RNA sequencing reveals a diverse and dynamic repertoire of the
Xenopus tropicalis
transcriptome over development
Meng How Tan
,
Kin Fai Au
,
Arielle L. Yablonovitch
,
Andrea E. Wills
,
Jason Chuang
,
Julie C. Baker
,
Wing Hung Wong
,
and
Jin Billy Li
Genome Res.
January 2013
23
:
201
-
216
;
Published in Advance
September 7, 2012
,
doi:
10.1101/gr.141424.112
...introns and in intergenic
regions
. We then developed a filtering pipeline to separate protein-coding transcripts from noncoding
RNAs
and identified a confident set of 6686 noncoding transcripts in 3859
genomic
loci. Since the current reference
genome
, XenTro3, consists of hundreds of scaffolds instead...
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Research
:
Epigenetic and evolutionary features of ape subterminal heterochromatin
DongAhn Yoo
,
Katherine M. Munson
,
and
Evan E. Eichler
Genome Res.
January 2026
36
:
38
-
49
;
Published in Advance
October 22, 2025
,
doi:
10.1101/gr.280987.125
...insertions and lineage-specific duplicated genes. Our findings suggest independent evolution of subterminal caps converging on a
common
genetic and epigenetic structure that promoted ectopic exchange as well as the emergence of novel genes at transition
regions
between euchromatin and heterochromatin...
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