Searching journal content for articles similar to Teng and Risch 9 (3): 234.

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  1. RESEARCH: The Relative Power of Family-Based and Case-Control Designs for Linkage Disequilibrium Studies of Complex Human Diseases I. DNA Pooling
    • Neil Risch and
    • Jun Teng
    Genome Res. December 1, 1998 8: 1273-1288; doi:10.1101/gr.8.12.1273
    ...The Relative Power of Family-Based and Case-Control Designs for Linkage Disequilibrium Studies of Complex Human Diseases I. DNA Pooling Neil Risch 1 , 2 , 3 , 4 and Jun Teng 3 Departments of 1Genetics and 2Health Research and Policy, Stanford...
  2. Methods: Genome-wide comparisons of variation in linkage disequilibrium
    • Yik Y. Teo,
    • Andrew E. Fry,
    • Kanishka Bhattacharya,
    • Kerrin S. Small,
    • Dominic P. Kwiatkowski,
    • and Taane G. Clark
    Genome Res. October 2009 19: 1849-1860; Published in Advance June 18, 2009, doi:10.1101/gr.092189.109
    ...disequilibrium (LD) (de Bakker et al. 2006a). Powerful analytical tools have also utilized the comprehensive information from these databases to increase genomic coverage and fine-map association signals through statistical imputation of untyped genetic variants that exist in the databases (Marchini et al. 2007...
  3. RECOMB Special/Methods: Increasing power in association studies by using linkage disequilibrium structure and molecular function as prior information
    • Eleazar Eskin
    Genome Res. April 2008 18: 653-660; Published in Advance March 18, 2008, doi:10.1101/gr.072785.107
    ...to measure the effect of intrinsic information, specifically linkage disequilibrium patterns in the HapMap, we assume that each polymorphism is equally likely to be causal and observe on average an increase in power that is equivalent to an increase in the number of individuals by 9%. In simulations of whole...
  4. LETTER: Haplotype Information and Linkage Disequilibrium Mapping for Single Nucleotide Polymorphisms
    • Xin Lu,
    • Tianhua Niu,
    • and Jun S. Liu
    Genome Res. September 2003 13: 2112-2117; doi:10.1101/gr.586803
    ...fine mapping, and haplotype inference should be carried out jointly with LD mapping; (2) for complex diseases, inferring haplotype phases for individuals prior to LD mapping helps achieve a better accuracy. An improved version of the linkage disequilibrium mapping program, BLADE v2, is available...
  5. REVIEW: Linkage Disequilibrium and the Search for Complex Disease Genes
    • L.B. Jorde
    Genome Res. October 1, 2000 10: 1435-1444; doi:10.1101/gr.144500
    ...– 104 . ↵ Teng J. , Risch N. ( 1999 ) The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. II. Individual genotyping. Genome Res. 9 : 234 – 241 . ↵ Terwilliger J.D. ( 1995 ) A powerful likelihood method for the analysis of linkage...
  6. METHODS: Trimming, Weighting, and Grouping SNPs in Human Case-Control Association Studies
    • Josephine Hoh,
    • Anja Wille,
    • and Jurg Ott
    Genome Res. December 1, 2001 11: 2115-2119; doi:10.1101/gr.204001
    ...between SNPs and case and control individuals. It will be important to find the most powerful statistic for such studies. Genotyping errors have deleterious effects on association and linkage disequilibrium analysis ( Akey et al. 2001 ) and thus will also affect our set-association method. If, in addition...
  7. METHODS: Genetic Analysis of Case/Control Data Using Estimated Haplotype Frequencies: Application to APOE Locus Variation and Alzheimer's Disease
    • Daniele Fallin,
    • Annick Cohen,
    • Laurent Essioux,
    • Ilya Chumakov,
    • Marta Blumenfeld,
    • Daniel Cohen,
    • and Nicholas J. Schork
    Genome Res. January 1, 2001 11: 143-151; doi:10.1101/gr.148401
    .... Hum. Genet. 64 : 1147 – 1157 . ↵ Ott J. ( 2000 ) Predicting the range of linkage disequilibrium. Proc. Natl. Acad. Sci. 97 : 2 – 3 . ↵ Ott J. , Rabinowitz D. ( 1997 ) The effect of marker heterozygosity on the power to detect linkage disequilibrium. Genetics 147 : 927 – 930 . ↵ Pritchard J...
  8. METHODS: Pooled Genotyping of Microsatellite Markers in Parent–Offspring Trios
    • George Kirov,
    • Nigel Williams,
    • Pak Sham,
    • Nick Craddock,
    • and Michael J. Owen
    Genome Res. January 1, 2000 10: 105-115; doi:10.1101/gr.10.1.105
    ...are a powerful alternative for locating genes of small effect in complex traits ( Owen and McGuffin 1993 ; Risch and Merikangas 1996 ). Genome-wide association studies using either case-control or family-based methods are much more sensitive than standard -wide affected-sib-pair linkage analyses ( Risch...
  9. LETTER: A Multilocus Genotyping Assay for Candidate Markers of Cardiovascular Disease Risk
    • Suzanne Cheng,
    • Michael A. Grow,
    • Céline Pallaud,
    • William Klitz,
    • Henry A. Erlich,
    • Sophia Visvikis,
    • John J. Chen,
    • Clive R. Pullinger,
    • Mary J. Malloy,
    • Gérard Siest,
    • and John P. Kane
    Genome Res. October 1, 1999 9: 936-949; doi:10.1101/gr.9.10.936
    ...power to detect one- and two-locus effects on risk for CVD, the intent of this analysis was to demonstrate how the CVD35 assay could be used to evaluate disease association and genotype interactions with a case-control study design. Given the exploratory nature of these preliminary analyses, no formal...
  10. LETTER: Genetic Structure Adds Power to Detect Schizophrenia Susceptibility at SLIT3 in the Chinese Han Population
    • YongYong Shi,
    • XinZhi Zhao,
    • Lan Yu,
    • Ran Tao,
    • JunXia Tang,
    • YuJuan La,
    • Yun Duan,
    • Bo Gao,
    • NiuFan Gu,
    • YiFeng Xu,
    • GuoYin Feng,
    • ShaoMin Zhu,
    • HuiJun Liu,
    • Hugh Salter,
    • and Lin He
    Genome Res. July 2004 14: 1345-1349; doi:10.1101/gr.1758204
    ...influence the detection power of subsequent analysis. (1) Reading the input of allele frequencies in SH's control, SH's case, NH's control, and NH's case, the program randomly generates the genotypes of each individual in a single simulation. (2) Based on the given correlated sampling structure of SH, NH...
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