Searching journal content for articles similar to Sutter et al. 14 (12): 2388.

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  1. ...of segmental duplications and associated copy number variants (CNVs) in the modern domesticated dog, Canis familiaris , which exhibits considerable morphological, physiological, and behavioral variation. Through computational analyses of the publicly available canine reference sequence, we estimate...
  2. ...in a number of dog breeds and several carnivores, we show here that this gene was inactivated early in canid evolution. We next use patterns of linkage disequilibrium using more than 170,000 SNP markers typed in almost 500 dogs to estimate the recombination rates in the dog genome using a coalescent...
  3. ...between recombination rate and GC content, as well as GC-rich sequence motifs. Levels of linkage disequilibrium (LD) were significantly higher in regions of low recombination, showing that heterogeneity in recombination rates have left a footprint on the genomic landscape of LD in zebra finch populations...
  4. ...to group according to breed classes. Our combined findings suggest many CNVs are (1) in linkage disequilibrium with flanking sequence, and (2) associated with breed-specific traits. We discuss how a catalog of structural variation in dogs will accelerate the identification of the genetic basis of canine...
  5. ...and extensive linkage disequilibrium, may also increase the difficulty associated with fine mapping and identifying causative mutations. One way to address this problem is by combining data from multiple breeds segregating the same trait after initial linkage has been determined. The multibreed approach...
  6. ...traits and vary in behavior and the incidence of genetic disease, genomic-wide scans for linkage disequilibrium may allow the discovery of genes influencing breed-specific characteristics. Finally, we review studies that have utilized the dog to understand the genetic underpinning of several traits...
  7. ...in the cat than FeLV or RD114 sequences ( Fig. 4 ; Supplemental Fig. S3; Table 3 ). Identification of 327,000 new SNPs, 208,177 new STR loci, and a mosaic pattern of homozygosity useful for linkage disequilibrium mapping of complex traits in the cat ( Fig. 5 ). A dynamic online browser of Genome Annotation...
  8. ...contexts. Also, although possible, performing CRISPR-Cas9 in dogs is expensive and inefficient, and animal use issues are a major concern (Zou et al. 2015; Tian et al. 2023). Variant prioritization is also made more challenging in dogs owing to extensive linkage disequilibrium (LD) caused by breeding...
  9. ....J., Kirkness, E.F., Kruglyak, L., and Ostrander, E.A. 2004 . Extensive and breed-specific linkage disequilibrium in Canis familiaris. Genome Res. 14 : 2388 -2396. ↵ Szabo, Z., Levi-Minzi, S.A., Christiano, A.M., Struminger, C., Stoneking, M., Batzer, M.A., and Boyd, C.D. 1999 . Sequential loss of two...
  10. ...., and Ostrander, E.A. 2004 . Extensive and breed-specific linkage disequilibrium in Canis familiaris. Genome Res. 14 : 2388 -2396. ↵ Thomas, R., Smith, K.C., Gould, R., Gower, S.M., Binns, M.M., and Breen, M. 2001 . Molecular cytogenetic analysis of a novel high-grade canine T-lymphoblastic lymphoma demonstrating...
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