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  1. ...for the formation of nuclear paraspeckles (Sunwoo et al. 2009). In addition, >25% of lncRNA genes show evidence of alternative splicing with at least two different transcript isoforms per gene locus (Fig. 3D). Themost highly spliced lncRNA gene is PCBP1-AS1 with 40 annotated isoforms. This human lncRNA gene...
  2. ...-splicing of group I introns. Annu Rev Biochem 59: 543–568. Cech TR, Steitz JA. 2014. The noncoding RNA revolution-trashing old rules to forge new ones. Cell 157: 77–94. Chalei V, Sansom SN, Kong L, Lee S, Montiel JF, Vance KW, Ponting CP. 2014. The long non-coding RNADali is an epigenetic regulator of neural...
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  3. .... 2011). Surprisingly, given its identification as a functional ‘‘architectural’’ RNA and similar to Friedel et al. (2009),Neat1 was very unstable with a half-life of <30 min by array and 15 min by qPCR (Fig. 7B). As Neat1 is unspliced and has short, ;3.2 kb (Neat1_v1/Men epsilon) and long, ;20 kb (Neat1...
  4. ...Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals Hidenori Tani 1 , Rena Mizutani 1 , Kazi Abdus Salam 1 , Keiko Tano 1 , Kenichi Ijiri 1 , Ai Wakamatsu 2 , Takao Isogai...
  5. ..., including 48 families with known structural RNA elements. Known families identified include both noncoding RNAs, e.g., miRNAs and the recently identified MALAT1/MEN β lincRNA family; and cis -regulatory structures, e.g., iron-responsive elements. We also identify tens of new families supported...
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