Searching journal content for articles similar to Subasic et al. 25 (11): 1680.

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  1. ...of microRNA dynamics at the single-cell level.microRNAs (miRNAs) are ∼22 nucleotide (nt) small noncoding RNAs that guide Argonaute effector proteins to target mRNAs in a sequence-specific manner, leading to their translational inhibition and increased degradation through deadenylation and decapping (Bartel...
  2. ...targeted mRNAs and mitigate truncated protein production. The presence of independent degradation pathways conflicts with genetic evidence supporting the requirement of all of SMG-1 through SMG-7 in Caenorhabditis elegans’ NMD (Hodgkin et al. 1989; Cali et al. 1999; Anders et al. 2003).A contemporary SMG-5...
  3. ...of these differences was generally smaller (Fig. 4E; Supplemental Fig. S6A). Together, these observations suggest that mRNA turnover rates are globally regulated across both developmental stages and cell types.Small RNA pathways such as the microRNA pathway are thought to target specific subsets of genes...
  4. ...), but our long RNA-seq mappings could also be consistent with TR transcription in C. elegans being a byproduct of mRNA transcription.View larger version: In this window In a new window Figure 6. Transcription from a tandem repeat in various tissue types. This shows an alignment of long RNA-seq reads...
  5. ...in the target mRNAs. Similar to most other steps in the gene expression pathway, mRNA degradation is often coordinated with upstream and downstream steps. For example, mRNA translation and decay are strongly interconnected in the context of mRNA surveillance pathways (Bicknell and Ricci 2017; Morris et al. 2021...
  6. ...of dormancy is rudimentary and remains an obstacle to advancing fundamental knowledge about dormancy that may pave the way to improved in vitro technologies.microRNAs (miRNAs) are processed small noncoding RNAs that adjust expression levels of target genes mostly by translational interference or mRNA...
  7. ...Methodist Research Institute, Houston, TX 77030, USA Corresponding author: geneyeo@ucsd.eduAbstractTranscription and translation are intertwined processes in which mRNA isoforms are crucial intermediaries. However, methodological limitations in analyzing translation at the mRNA isoform level have left gaps...
  8. ...for further regulatory analysis (Supplemental File S9; modERNresource GitHub, https://github.com/modERNresource).Distribution of peaks and metapeaks relative to protein-coding genesTo evaluate the correlation between TF binding sites and mRNA abundance as measured in other experiments, we assigned the binding...
  9. ...Medical University (Naval Medical University), Shanghai 200433, China; 2Center for Translational Medicine, Second Military Medical University (Naval Medical University), Shanghai 200433, China; 3National Key Laboratory of Immunity and Inflammation, Institute of Immunology, Naval Medical University...
  10. ...-dependent and that this regulation modulates the transcription of genes involved in cell adhesion and mRNA translation in colorectal cancer cells. Proteomic analyses reveal that ACTB and SETD3 interact with multiple large protein complexes, including complexes associated with transcriptional regulation...
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