Searching journal content for articles similar to Stumpferl et al. 22 (10): 1963.

Displaying results 1-10 of 58
For checked items
  1. Research: Natural diversity of telomere length distributions across 100 Saccharomyces cerevisiae strains
    • Clotilde Garrido,
    • Cintia Gómez-Muñoz,
    • Etienne Kornobis,
    • Nicolas Agier,
    • Oana Ilioaia,
    • Gilles Fischer,
    • and Zhou Xu
    Genome Res. March 2026 36: 522-533; Published in Advance January 16, 2026, doi:10.1101/gr.281132.125
    ...distribution at each individual chromosome extremity and globally for 100 natural yeast strains. We aim at providing a representative view of TL diversity in S. cerevisiae and propose to uncover several features that may underlie TL variations both within and across s.ResultsSingle-molecule sequencing provides...
  2. Research: Variation in the fitness impact of translationally optimal codons among animals
    • Florian Bénitière,
    • Tristan Lefébure,
    • and Laurent Duret
    Genome Res. March 2025 35: 446-458; Published in Advance February 10, 2025, doi:10.1101/gr.279837.124
    ...variation in the intensity in TS across animals, it is important to refer to population genetic principles (Ohta 1996). Indeed, the SCU in a given reflects a balance between selection favoring translationally optimal codons and the effects of mutation and drift, allowing the fixation of nonoptimal codons...
  3. Research: Copy number variation alters local and global mutational tolerance
    • Grace Avecilla,
    • Pieter Spealman,
    • Julia Matthews,
    • Elodie Caudal,
    • Joseph Schacherer,
    • and David Gresham
    Genome Res. August 2023 33: 1340-1353; Published in Advance August 31, 2023, doi:10.1101/gr.277625.122
    ...of differing sizes and structures. Here, we investigated Saccharomyces cerevisiae (yeast) strains that acquired adaptive CNVs of variable structures and copy numbers following experimental evolution in glutamine-limited chemostats. Although beneficial in the selective environment, CNVs result in decreased...
    OPEN ACCESS ARTICLE
  4. Research: Variation in mutation, recombination, and transposition rates in Drosophila melanogaster and Drosophila simulans
    • Yiguan Wang,
    • Paul McNeil,
    • Rashidatu Abdulazeez,
    • Marta Pascual,
    • Susan E. Johnston,
    • Peter D. Keightley,
    • and Darren J. Obbard
    Genome Res. April 2023 33: 587-598; Published in Advance April 10, 2023, doi:10.1101/gr.277383.122
    ....6 cM/Mb (Hemmer et al. 2020), and D. melanogaster of 2.5 cM/Mb (Comeron et al. 2012). However, experimental studies of Drosophila have rarely looked at variation in -wide recombination rates in natural populations of outbred individuals, and wild populations may differ systematically from populations...
    OPEN ACCESS ARTICLE
  5. Research: Natural genetic variation in C. elegans identified genomic loci controlling metabolite levels
    • Arwen W. Gao,
    • Mark G. Sterken,
    • Jelmi uit de Bos,
    • Jelle van Creij,
    • Rashmi Kamble,
    • Basten L. Snoek,
    • Jan E. Kammenga,
    • and Riekelt H. Houtkooper
    Genome Res. September 2018 28: 1296-1308; Published in Advance August 14, 2018, doi:10.1101/gr.232322.117
    ...the natural phenotypical variation in a population to identify causal genetic variants (Williams and Auwerx 2015). This involves classic mutagenesis screens and techniques such as quantitative trait loci (QTL) analysis and -wide association studies (GWAS). QTL analysis is a statistical technique that examines...
    OPEN ACCESS ARTICLE
  6. Research: Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populations
    • Liam C. Hunt,
    • Jianqin Jiao,
    • Yong-Dong Wang,
    • David Finkelstein,
    • Deepti Rao,
    • Michelle Curley,
    • Maricela Robles-Murguia,
    • Abbas Shirinifard,
    • Vishwajeeth R. Pagala,
    • Junmin Peng,
    • Yiping Fan,
    • and Fabio Demontis
    Genome Res. August 2019 29: 1262-1276; Published in Advance June 27, 2019, doi:10.1101/gr.246884.118
    ...of the environment and to synchronize social activities. Although the circadian cycle is implicated in aging, it is unknown whether natural variation in its function contributes to differences in lifespan between populations and whether the circadian clock of specific tissues is key for longevity. We have sequenced...
  7. Research: Intragenic repeat expansion in the cell wall protein gene HPF1 controls yeast chronological aging
    • Benjamin P. Barré,
    • Johan Hallin,
    • Jia-Xing Yue,
    • Karl Persson,
    • Ekaterina Mikhalev,
    • Agurtzane Irizar,
    • Sylvester Holt,
    • Dawn Thompson,
    • Mikael Molin,
    • Jonas Warringer,
    • and Gianni Liti
    Genome Res. May 2020 30: 697-710; Published in Advance April 10, 2020, doi:10.1101/gr.253351.119
    ...), and have never been exposed to natural selection (Kaya et al. 2015). Thus, genetic variants that control natural life span variation are still largely unknown. Crosses between natural yeast strains have the potential to uncover these variants (Brem 2002; Steinmetz et al. 2002) but remain poorly explored...
    OPEN ACCESS ARTICLE
  8. Research: Natural variation of histone modification and its impact on gene expression in the rat genome
    • Carola Rintisch,
    • Matthias Heinig,
    • Anja Bauerfeind,
    • Sebastian Schafer,
    • Christin Mieth,
    • Giannino Patone,
    • Oliver Hummel,
    • Wei Chen,
    • Stuart Cook,
    • Edwin Cuppen,
    • Maria Colomé-Tatché,
    • Frank Johannes,
    • Ritsert C. Jansen,
    • Helen Neil,
    • Michel Werner,
    • Michal Pravenec,
    • Martin Vingron,
    • and Norbert Hubner
    Genome Res. June 2014 24: 942-953; Published in Advance May 2, 2014, doi:10.1101/gr.169029.113
    ...Natural variation of histone modification and its impact on gene expression in the rat genome Carola Rintisch 1 , 12 , Matthias Heinig 1 , 2 , 12 , Anja Bauerfeind 1 , Sebastian Schafer 1 , Christin Mieth 1 , Giannino Patone 1...
  9. Research: Intergenic accumulation of RNA polymerase II maintains the potential for swift transcriptional restart upon release from quiescence
    • Manuela Baquero Pérez,
    • Gertjan Laenen,
    • Isabelle Loïodice,
    • Mickaël Garnier,
    • Ugo Szachnowski,
    • Antonin Morillon,
    • Myriam Ruault,
    • and Angela Taddei
    Genome Res. October 2025 35: 2226-2239; Published in Advance August 12, 2025, doi:10.1101/gr.279874.124
    ...-enter the cell cycle upon sensing of external cues. Q cells are responsive to the environment and flexible enough to adapt to available resources. In budding yeast, quiescent nuclear features are drastically distinct from those observed in nutrient replete conditions: The nuclear volume is reduced; the telomeres...
  10. Research: Mendelian randomization analyses implicate biogenesis of translation machinery in human aging
    • Sara Javidnia,
    • Stephen Cranwell,
    • Stefanie H. Mueller,
    • Colin Selman,
    • Jennifer M.A. Tullet,
    • Karoline Kuchenbaecker,
    • and Nazif Alic
    Genome Res. February 2022 32: 258-265; Published in Advance January 25, 2022, doi:10.1101/gr.275636.121
    ...longevity corresponds in scale to the natural, genetically encoded variation observed in human populations. Hence, it is likely that the relative reduction in biogenesis of the translation machinery that promotes longevity has substantially less effect on overall cellular capacity for translation than do...
    OPEN ACCESS ARTICLE
For checked items

Search Results

Next 10 » New Search

Modify Results

Citation format:
Results / page:
Results order:

This search

  • Alert me when new articles matching this search are published
  • Download all citations on this page to my citation manager

Preprint Server



Current Issue

  1. March 2026, 36 (3)
  1. Current Issue
  1. Alert me to new issues of Genome Research