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Resource: Binding profiles for 961 Drosophila and C. elegans transcription factors reveal tissue-specific regulatory relationships
- Michelle Kudron,
- Louis Gevirtzman,
- Alec Victorsen,
- Bridget C. Lear,
- Jiahao Gao,
- Jinrui Xu,
- Swapna Samanta,
- Emily Frink,
- Adri Tran-Pearson,
- Chau Huynh,
- Dionne Vafeados,
- Ann Hammonds,
- William Fisher,
- Martha Wall,
- Greg Wesseling,
- Vanessa Hernandez,
- Zhichun Lin,
- Mary Kasparian,
- Kevin White,
- Ravi Allada,
- Mark Gerstein,
- LaDeana Hillier,
- Susan E. Celniker,
- Valerie Reinke,
- and Robert H. Waterston
Genome Res. December 2024 34: 2319-2334; Published in Advance October 22, 2024, doi:10.1101/gr.279037.124
...C. elegans and the fruit fly Drosophila melanogaster were selected for the modENCODE Project in 2007 because of their experimental strengths and prominence as model organisms as well as for their compact, sequenced s, which simplifies the identification of TF binding sites and candidate target genes...
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Resource: Streamlined spatial and environmental expression signatures characterize the minimalist duckweed Wolffia australiana
- Tom Denyer,
- Pin-Jou Wu,
- Kelly Colt,
- Bradley W. Abramson,
- Zhili Pang,
- Pavel Solansky,
- Allen Mamerto,
- Tatsuya Nobori,
- Joseph R. Ecker,
- Eric Lam,
- Todd P. Michael,
- and Marja C.P. Timmermans
Genome Res. July 2024 34: 1106-1120; Published in Advance July 1, 2024, doi:10.1101/gr.279091.124
...are evident, with select cells showing unique transcriptomic signatures associated with developmental maturation and specialized physiologies. Assessing this simplified biological system temporally at two key time-of-day (TOD) transitions, we identify additional TOD-responsive genes previously overlooked...
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Resource: A spatiotemporally resolved atlas of mRNA decay in the C. elegans embryo reveals differential regulation of mRNA stability across stages and cell types
- Felicia Peng,
- C. Erik Nordgren,
- and John Isaac Murray
Genome Res. August 2024 34: 1235-1252; Published in Advance August 14, 2024, doi:10.1101/gr.278980.124
...regulatory mechanisms.Development is a highly regulated process that relies on the precise spatial and temporal control of gene expression patterns. Although transcriptional regulation is heavily studied, the regulation of mRNA decay can also be complex and necessarily influences mRNA abundance (Alonso 2012...
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Research: Characterization of the distribution and dynamics of chromatin states in the C. elegans germline reveals substantial H3K4me3 remodeling during oogenesis
- Mariateresa Mazzetto,
- Lauren E. Gonzalez,
- Nancy Sanchez,
- and Valerie Reinke
Genome Res. January 2024 34: 57-69; Published in Advance December 26, 2023, doi:10.1101/gr.278247.123
....Using chromatin states to understand germline regulatory mechanismsThe C. elegans germline is characterized by an organized trajectory along which proliferating germ cells enter meiosis I and either differentiate into sperm at the L4 stage or into oocytes as adults. These temporal and spatial dynamics result...
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Research: Natural variation in C. elegans short tandem repeats
- Gaotian Zhang,
- Ye Wang,
- and Erik C. Andersen
Genome Res. October 2022 32: 1852-1861; Published in Advance October 4, 2022, doi:10.1101/gr.277067.122
..., Schulenburg H. 2005. Evolutionary history of Caenorhabditis elegans inferred from microsatellites: evidence for spatial and temporal genetic differentiation and the occurrence of outbreeding. Mol Biol Evol 22: 160–173. doi:10.1093/molbev/msh264 ↵Hahnel SR, Zdraljevic S, Rodriguez BC, Zhao Y, McGrath PT...
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Perspective: Advances in spatial transcriptomic data analysis
- Ruben Dries,
- Jiaji Chen,
- Natalie del Rossi,
- Mohammed Muzamil Khan,
- Adriana Sistig,
- and Guo-Cheng Yuan
Genome Res. October 2021 31: 1706-1718; doi:10.1101/gr.275224.121
...and the resulting spatial transformations mapped back to the transcriptomic data in order to create an aligned 3D gene expression data set. This is illustrated with the breast cancer spatial transcriptomics data set from Andersson et al. (2020b). (C) Several methods exist to provide expression data with spatial...
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Research: Global regulatory features of alternative splicing across tissues and within the nervous system of C. elegans
- Bina Koterniak,
- Pallavi P. Pilaka,
- Xicotencatl Gracida,
- Lisa-Marie Schneider,
- Iva Pritišanac,
- Yun Zhang,
- and John A. Calarco
Genome Res. December 2020 30: 1766-1780; Published in Advance October 30, 2020, doi:10.1101/gr.267328.120
...in a particular sample.We first mapped our TRAP-seq reads to the C. elegans and to existing gene models (for details, see Methods) and identified all aligned reads supporting annotated splice junctions, as well as high-confidence unannotated splice junctions. In total, we detected 145,811 splice junctions...
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Resource: The time-resolved transcriptome of C. elegans
- Max E. Boeck,
- Chau Huynh,
- Lou Gevirtzman,
- Owen A. Thompson,
- Guilin Wang,
- Dionna M. Kasper,
- Valerie Reinke,
- LaDeana W. Hillier,
- and Robert H. Waterston
Genome Res. October 2016 26: 1441-1450; Published in Advance August 16, 2016, doi:10.1101/gr.202663.115
...detailed RNA-seq data for the nematode Caenorhabditis elegans with high temporal resolution in the embryo as well as representative samples from post-embryonic stages across the life cycle. The data reveal that early and late embryogenesis is accompanied by large numbers of genes changing expression...
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Resource: Direct full-length RNA sequencing reveals unexpected transcriptome complexity during Caenorhabditis elegans development
- Runsheng Li,
- Xiaoliang Ren,
- Qiutao Ding,
- Yu Bi,
- Dongying Xie,
- and Zhongying Zhao
Genome Res. February 2020 30: 287-298; Published in Advance February 5, 2020, doi:10.1101/gr.251512.119
...splicing events by using the mapping tracks of full-length RNA transcripts, which allowed us to identify 57,000 novel isoforms that are absent in the current annotation. We detected putative stage-specific expression of isoforms that was independent of the stage-specific expression of genes. Finally, we...
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Resource: Chromatin accessibility dynamics reveal novel functional enhancers in C. elegans
- Aaron C. Daugherty,
- Robin W. Yeo,
- Jason D. Buenrostro,
- William J. Greenleaf,
- Anshul Kundaje,
- and Anne Brunet
Genome Res. December 2017 27: 2096-2107; Published in Advance November 15, 2017, doi:10.1101/gr.226233.117
...-seq requires orders of magnitude less input than a single ChIP-seq.ATAC-seq identifies new distal regulatory regions that serve as tissue- and stage-specific enhancers in C. elegansEnhancers are key regulators of temporal- and tissue-specific gene expression that play important and conserved functions during...
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