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  1. ...Intronic Sequences Flanking Alternatively Spliced Exons Are Conserved Between Human and Mouse Rotem Sorek 1 , 2 and Gil Ast 1 , 3 1 Department of Human Genetics, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel 2...
  2. ...Sequencing Project Consortium. 2004 . Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428 : 493 -521. ↵ Sorek, R., Ast, G., and Graur, D. 2002 . Alu -containing exons are alternatively spliced. Genome Res. 12 : 1060 -1067. ↵ Springer, M.S., Murphy, W.J., Eizirik, E...
  3. ...) and percentage of splice site combinations associated with each AS class (right). (SE) Skipping exons, (RI) retained introns, (A5SS) alternative 5′ splice sites, (A3SS) alternative 3′ splice sites, (MEX) mutually exclusive exons. (C) Number of annotated genes with novel detected peptides in each species for Uni...
  4. ...examined the sequence conservation of non-Alu-containing exons with 3′ss editing sites across 46 vertebrates spanning primates to fish (Siepel et al. 2005). Since these exons demonstrated multiple types of alternative splicing in the RNA-seq data (Fig. 3B) and because different types of alternative...
  5. ...; Zorio and Blumenthal 1999). These early steps in spliceosome assembly play critical roles in defining exon–intron boundaries.HNRNPA1 is a well-characterized regulator of alternative splicing. One of the primary functions of HNRNPA1 is to prevent inclusion of specific exons (Mayeda and Krainer 1992...
  6. ...Alu sequences. Recently, we showed that a subset of those mapping to introns can alter mRNA splicing of nearby exons (Payer et al. 2019), and that is likely just one of many functional consequences of polymorphic Alu elements.Retrotransposons have intrinsic sequences that regulate expression...
  7. ...of short (black), medium (dark gray), and long (light gray) genes (boxes indicate exons). (B) An inverse relationship between a gene’s number of alternatively spliced variants and its family size, as previously characterized (Kopelmanet al. 2005). Theboxplot indicates themedian,mean (circle), and25%and75...
  8. ...Acids Res. 31 : 1067 –1074. ↵ Sorek, R., Ast, G., and Graur, D. 2002 . Alu-containing exons are alternatively spliced. Genome Res. 12 : 1060 –1067. ↵ Sorek, R., Shamir, R., and Ast, G. 2004 . How prevalent is functional alternative splicing in the human ? Trends Genet. 20 : 68 –71. ↵ Thanaraj, T...
  9. ...). Thus, treating each macrophage condition (nonstimulated, IFNG/TNF-stimulated, CpG-stimulated, and Toxoplasma-infected) as an independent cohort, we calculated the PSI values for each splicing event in each of the 28 samples. Of the 16,974 annotated exon-centric and 39 UTR alternative events (Wang et al...
  10. .... ( 2005 ) Comparative sequencing of Drosophila pseudoobscura : Chromosomal, gene, and cis -element evolution. Genome Res. 15 : 1 – 18 . ↵ Sorek R. , Ast G. , Graur D. ( 2002 ) Alu -containing exons are alternatively spliced. Genome Res. 12 : 1060 – 1067 . ↵ Stolc V. , Gauhar Z. , Mason C. , Halasz G...
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