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Method: An extended set of yeast-based functional assays accurately identifies human disease mutations
- Song Sun,
- Fan Yang,
- Guihong Tan,
- Michael Costanzo,
- Rose Oughtred,
- Jodi Hirschman,
- Chandra L. Theesfeld,
- Pritpal Bansal,
- Nidhi Sahni,
- Song Yi,
- Analyn Yu,
- Tanya Tyagi,
- Cathy Tie,
- David E. Hill,
- Marc Vidal,
- Brenda J. Andrews,
- Charles Boone,
- Kara Dolinski,
- and Frederick P. Roth
Genome Res. May 2016 26: 670-680; Published in Advance March 14, 2016, doi:10.1101/gr.192526.115
...a platform for functional analysis even in the absence of orthology. Examples include yeastbased genetic assays for interaction between two human proteins or between a protein and DNA. In one study, variants of the HsABCB1 gene, encoding themajor efflux pump (also called P-glycoprotein), were functionally...
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REVIEW: The Human ATP-Binding Cassette (ABC) Transporter Superfamily
- Michael Dean,
- Andrey Rzhetsky,
- and Rando Allikmets
Genome Res. July 1, 2001 11: 1156-1166; Published in Advance January 18, 2001, doi:10.1101/gr.184901
...that cannot be delivered by diffusion. ABCB1 also affects the pharmacology of the drugs that are substrates and a common polymorphism in the gene affects digoxin uptake ( Hoffmeyer et al. 2000 ). ABCC1 The ABCC1 gene was identified in the small-cell lung carcinoma cell line NCI-H69, a multidrug resistant cell...

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