Searching journal content for articles similar to Smith et al. 19 (8): 1325.

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  1. Perspective: The genetics and epigenetics of satellite centromeres
    • Paul B. Talbert and
    • Steven Henikoff
    Genome Res. April 2022 32: 608-615; Published in Advance March 31, 2022, doi:10.1101/gr.275351.121
    ...to segregate chromosomes, are typically found within satellite arrays in plants and animals. Satellite arrays have been difficult to analyze because they comprise megabases of tandem head-to-tail highly repeated DNA sequences. Much evidence suggests that centromeres are epigenetically defined by the location...
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  2. Research: Combinatorial microRNA activity is essential for the transition of pluripotent cells from proliferation into dormancy
    • Dhanur P. Iyer,
    • Lambert Moyon,
    • Lars Wittler,
    • Chieh-Yu Cheng,
    • Francisca R. Ringeling,
    • Stefan Canzar,
    • Annalisa Marsico,
    • and Aydan Bulut-Karslioğlu
    Genome Res. April 2024 34: 572-589; Published in Advance May 6, 2024, doi:10.1101/gr.278662.123
    ...and others have revealed significant rewiring of the metabolic, epigenetic, and transcriptomic signatures of cells in this transition (Fu et al. 2014; Boroviak et al. 2015; Hussein et al. 2020; Collignon et al. 2023; Iyer et al. 2023; van der Weijden et al. 2024). Among these are altered RNA methylation...
  3. Research: Parental methylome reprogramming in human uniparental blastocysts reveals germline memory transition
    • Jiawei Xu,
    • Yimin Shu,
    • Guidong Yao,
    • Yu Zhang,
    • Wenbin Niu,
    • Yile Zhang,
    • Xueshan Ma,
    • Haixia Jin,
    • Fuli Zhang,
    • Senlin Shi,
    • Yang Wang,
    • Wenyan Song,
    • Shanjun Dai,
    • Luyao Cheng,
    • Xiangyang Zhang,
    • Wei Xie,
    • Aaron J. Hsueh,
    • and Yingpu Sun
    Genome Res. September 2021 31: 1519-1530; Published in Advance July 30, 2021, doi:10.1101/gr.273318.120
    ...in the AG and GG blastocysts. Novel candidate imprinted DMRs were also identified. The production of uniparental human embryos followed by transcriptome and methylome analysis is valuable for identifying parental contributions and epi memory transitions during early human development.Uniparental embryos...
  4. Method: Chromatin module inference on cellular trajectories identifies key transition points and poised epigenetic states in diverse developmental processes
    • Sushmita Roy and
    • Rupa Sridharan
    Genome Res. July 2017 27: 1250-1262; Published in Advance April 19, 2017, doi:10.1101/gr.215004.116
    ...points, and conditions (Roadmap Epigenomics Consortium et al. 2015), approaches like CMINT will become increasingly useful to examine the chromatin state dynamics and identify important epigenetic transitions changing global cellular states. Methods ChIP-chip experiments ChIP-chip experiments were...
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  5. Research: Modest increase in the de novo single-nucleotide mutation rate in house mice born by assisted reproduction
    • Laura Blanco-Berdugo,
    • Alexis Garretson,
    • and Beth L. Dumont
    Genome Res. January 2026 36: 50-60; Published in Advance November 13, 2025, doi:10.1101/gr.281180.125
    ...in the transition/transversion ratio, the mutation spectrum, or the genomic distribution of dnSNVs between cohorts. Similarly, we observe no differential enrichment of dnSNVs across various epigenetic contexts or with respect to GC content, local transcriptional activity, or replication timing.Future studies...
  6. Method: Single-nucleus CUT&RUN elucidates the function of intrinsic and genomics-driven epigenetic heterogeneity in head and neck cancer progression
    • Howard J. Womersley,
    • Daniel Muliaditan,
    • Ramanuj DasGupta,
    • and Lih Feng Cheow
    Genome Res. January 2025 35: 162-177; Published in Advance December 2, 2024, doi:10.1101/gr.279105.124
    ...have limited application for discerning epigenetically distinct subpopulations within tumors. This makes it difficult to determine whether plasticity or lineage transitions are a result of Darwinian selection of rare, pre-existing clones, or adaptation, in which dynamic epigenetic changes may activate...
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  7. Research: Epigenetic and evolutionary features of ape subterminal heterochromatin
    • DongAhn Yoo,
    • Katherine M. Munson,
    • and Evan E. Eichler
    Genome Res. January 2026 36: 38-49; Published in Advance October 22, 2025, doi:10.1101/gr.280987.125
    ...insertions and lineage-specific duplicated genes. Our findings suggest independent evolution of subterminal caps converging on a common genetic and epigenetic structure that promoted ectopic exchange as well as the emergence of novel genes at transition regions between euchromatin and heterochromatin...
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  8. Resource: Epigenomics of embryogenesis in turbot
    • Oscar Aramburu,
    • Belen G Pardo,
    • Ada Jimenez-Gonzalez,
    • Andrés Blanco-Hortas,
    • Daniel Macqueen,
    • Carmen Bouza,
    • and Paulino Martinez
    Genome Res. November 4, 2025 gr.280355.124; Published in Advance November 4, 2025, doi:10.1101/gr.280355.124
    ...cell. This process is orchestrated by changes 11 in transcriptional regulation, influenced by chromatin accessibility and 12 epigenetic modifications, enabling transcription factor accessibility. Epigenomic 13 regulation of embryogenesis has been studied in model fish, but little attention 14 has been...
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  9. Review: The superpowers of imprinting control regions
    • Bertille Montibus,
    • Franck Court,
    • and Philippe Arnaud
    Genome Res. January 2026 36: 1-19; Published in Advance December 10, 2025, doi:10.1101/gr.281215.125
    ...). These regions are essential for regulating approximately 200 imprinted genes in mammals, which are expressed in a parent-of-origin-specific manner. ICRs are emerging as “Swiss-army knife” regulatory elements that, by integrating epigenetic signals and influencing the three-dimensional (3D) chromatin structure...
  10. Research: Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition
    • Håvard Aanes,
    • Cecilia L. Winata,
    • Chi Ho Lin,
    • Jieqi P. Chen,
    • Kandhadayar G. Srinivasan,
    • Serene G.P. Lee,
    • Adrian Y.M. Lim,
    • Hajira Shreen Hajan,
    • Philippe Collas,
    • Guillaume Bourque,
    • Zhiyuan Gong,
    • Vladimir Korzh,
    • Peter Aleström,
    • and Sinnakaruppan Mathavan
    Genome Res. August 2011 21: 1328-1338; Published in Advance May 9, 2011, doi:10.1101/gr.116012.110
    ...Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition Håvard Aanes 1 , 9 , Cecilia L. Winata 2 , 9 , Chi Ho Lin 3 , Jieqi P. Chen 4 , Kandhadayar G. Srinivasan 2 , Serene G...
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