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  1. ...models, outperforming both GBLUP and BayesR. These findings demonstrate a favorable trade-off between reduced accuracy (averaging <15%) and substantial computational savings, highlighting the practical value of dimensionality reduction in large-scale genomic analyses.View larger version: In this window...
  2. ..., and therapeutic perspective. Med Oncol 40: 71. doi:10.1007/s12032-022-01943-1 ↵Calvo-Roitberg E, Daniels RF, Pai AA. 2024. Challenges in identifying mRNA transcript starts and ends from long-read sequencing data. Genome Res 34: 1719–1734. doi:10.1101/gr.279559...
  3. ...Half dozen of one, six billion of the other: What can small- and large-scale molecular systems biology learn from one another? Ian A. Mellis 1 and Arjun Raj 2 1Perelman School of Medicine, Genomics and Computational Biology Graduate Group, University...
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  4. ...cells (Trottier et al. 1995).The continuous discovery of new TR expansion mutations in the 1990s fully leveraged the power of the Human Genome Project, as the huge numbers of sequence-tagged site (STS) markers that became available enabled fine mapping of the disease loci. Today, locus mapping can...
  5. ...analysis and for hypothesis testing (Guillot et al. 2009; Allendorf et al. 2010; Novembre and Peter 2016).As sequencing technology advances, large-scale whole- sequencing is becoming possible not only for describing genetic variation among species, but also for reporting similarities and differences among...
  6. ...through the Genome Research Open Access option. 23:889–904 2013, Published by Cold Spring Harbor Laboratory Press; ISSN 1088-9051/13; www..org Genome Research 889 www..org repositories. And lastly, while single sequence/species prediction of transcription factor binding sites results in far toomany...
  7. ...Changing perspectives in yeast research nearly a decade after the genome sequence Kara Dolinski and David Botstein 1 Lewis-Sigler Institute for Integrative Genomics, Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08544 USA...
  8. ...as paired-end sequencingusing traditionalmethods. After the successful assembly of the human (International Human Genome Sequencing Consortium 2001; Venter et al. 2001) and mouse (Waterston et al. 2002) s by whole- shotgun sequencing, most large-scale projects quickly moved to adopt the WGS approach, which...
  9. .../haplotypes with osteoporosis. A shift in large-scale strategies from genotyping to resequencing is currently taking place to explore the significance of less-common SNPs to human biology and disease. The “re” in this approach is the sequencing of additional s related to a reference for de novo SNP discovery and comparative...
  10. .... Bacteriol. 185 : 155 -164. ↵ Dolinski, K. and Botstein, D. 2005 . Changing perspectives in yeast research nearly a decade after the sequence. Genome Res. (this issue). ↵ Doolittle, W.F. 1999 . Phylogenetic classification and the universal tree. Science 284 : 2124 -2129. ↵ Douglas, S., Zauner, S., Fraunholz...
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