Searching journal content for articles similar to Smeds et al. 26 (9): 1211.

Displaying results 1-10 of 92

For checked items

view abstracts
download to citation manager

Select this article
Research: Extensive variation in germline de novo mutations in Poecilia reticulata
- Yuying Lin,
- Iulia Darolti,
- Wouter van der Bijl,
- Jake Morris,
- and Judith E. Mank
Genome Res. August 2023 33: 1317-1324; Published in Advance July 13, 2023, doi:10.1101/gr.277936.123
...or false positives should affect all families similarly, allowing for direct comparisons.Moreover, compared to other poikilothermic species, the absolute value of the mutation rate in the guppy is similar to whole pedigree-based estimates in poikilotherms, and also similar to rates seen in some endothermic...
Select this article
Research: Paternal age in rhesus macaques is positively associated with germline mutation accumulation but not with measures of offspring sociability
- Richard J. Wang,
- Gregg W.C. Thomas,
- Muthuswamy Raveendran,
- R. Alan Harris,
- Harshavardhan Doddapaneni,
- Donna M. Muzny,
- John P. Capitanio,
- Predrag Radivojac,
- Jeffrey Rogers,
- and Matthew W. Hahn
Genome Res. June 2020 30: 826-834; Published in Advance May 27, 2020, doi:10.1101/gr.255174.119
...genetic disorders. Mutational burden has been linked to complex disease, including neurodevelopmental disorders such as schizophrenia and autism. The rate of mutation is a fundamental genomic parameter and direct estimates of this parameter have been enabled by accurate comparisons of whole- sequences...
Select this article
Research: Developmental timing of programmed DNA elimination in Paramecium tetraurelia recapitulates germline transposon evolutionary dynamics
- Coralie Zangarelli,
- Olivier Arnaiz,
- Mickaël Bourge,
- Kevin Gorrichon,
- Yan Jaszczyszyn,
- Nathalie Mathy,
- Loïc Escoriza,
- Mireille Bétermier,
- and Vinciane Régnier
Genome Res. November/December 2022 32: 2028-2042; Published in Advance November 23, 2022, doi:10.1101/gr.277027.122
...-to-end joined circular molecules that are used as substrates for transcription and Dcl5-dependent production of iesRNAs, before being eventually degraded (Allen et al. 2017). The existence of multi-IES concatemers, however, was only supported by the sequencing of reverse-transcribed RNA molecules, and direct...
Select this article
Method: De novo mutation rates at the single-mutation resolution in a human HBB gene region associated with adaptation and genetic disease
- Daniel Melamed,
- Yuval Nov,
- Assaf Malik,
- Michael B. Yakass,
- Evgeni Bolotin,
- Revital Shemer,
- Edem K. Hiadzi,
- Karl L. Skorecki,
- and Adi Livnat
Genome Res. March 2022 32: 488-498; Published in Advance January 14, 2022, doi:10.1101/gr.276103.121
...of observable mutation types and the synonymous versus nonsynonymous mutation confound, further observations are in the expected direction (Supplemental Text S11). The correspondence observed could not have been predicted from the mutations’ GWA rates, even when adjusting for the genetic context (Supplemental...
OPEN ACCESS ARTICLE
Select this article
Research: Evolutionary expansion of DNA hypomethylation in the mammalian germline genome
- Jianghan Qu,
- Emily Hodges,
- Antoine Molaro,
- Pascal Gagneux,
- Matthew D. Dean,
- Gregory J. Hannon,
- and Andrew D. Smith
Genome Res. February 2018 28: 145-158; Published in Advance December 19, 2017, doi:10.1101/gr.225896.117
...methylation has substantially impacted the large-scale evolution of mammalian s. Spontaneous deamination elevates the mutation rate at methylated cytosines (Bird 1980). Consequently, germline DNA methylation profiles have shaped the CpG landscape of mammalian s (Cohen et al. 2011), resulting in the CpG island...
Select this article
Research: Phyloepigenomic comparison of great apes reveals a correlation between somatic and germline methylation states
- David I.K. Martin,
- Meromit Singer,
- Joseph Dhahbi,
- Guanxiong Mao,
- Lu Zhang,
- Gary P. Schroth,
- Lior Pachter,
- and Dario Boffelli
Genome Res. December 2011 21: 2049-2057; Published in Advance September 9, 2011, doi:10.1101/gr.122721.111
...have a higher rate of CG decay than SUMIs that are unmethylated in the neutrophil. Methylated CGs undergo mutation to TG (but not to AG or GG) much more frequently than unmethylated CGs (Coulondre et al. 1978). The mutation is heritable if it occurs in the germline; this is the basis...
Select this article
LETTER: CpG dinucleotides and the mutation rate of non-CpG DNA
- Jean-Claude Walser,
- Loïc Ponger,
- and Anthony V. Furano
Genome Res. September 2008 18: 1403-1414; Published in Advance June 11, 2008, doi:10.1101/gr.076455.108
...problems with this explanation. First, ancient repeats, far older than any analyzed here and likely more CpG-poor than any analyzed here, are not excluded from closed chromatin ( Prendergast et al. 2007 ). Therefore, recruitment of a given sequence into silent chromatin may not be a direct function of its...
Select this article
Letter: HapMap methylation-associated SNPs, markers of germline DNA methylation, positively correlate with regional levels of human meiotic recombination
- Martin I. Sigurdsson,
- Albert V. Smith,
- Hans T. Bjornsson,
- and Jon J. Jonsson
Genome Res. April 2009 19: 581-589; Published in Advance January 21, 2009, doi:10.1101/gr.086181.108
...stretches of DNA in sperm. This is, to date, the largest data release of direct DNA methylation measurements. We found that the average methylation was significantly higher in amplicons located within recombination hot spots compared with amplicons that are not. Furthermore, the distribution of amplicons...
Select this article
LETTER: Analysis of sequence variability in the macronuclear DNA of Paramecium tetraurelia: A somatic view of the germline
- Laurent Duret,
- Jean Cohen,
- Claire Jubin,
- Philippe Dessen,
- Jean-François Goût,
- Sylvain Mousset,
- Jean-Marc Aury,
- Olivier Jaillon,
- Benjamin Noël,
- Olivier Arnaiz,
- Mireille Bétermier,
- Patrick Wincker,
- Eric Meyer,
- and Linda Sperling
Genome Res. April 2008 18: 585-596; Published in Advance February 6, 2008, doi:10.1101/gr.074534.107
...are consistent with selection acting on IESs that interrupt coding sequences to ensure that excision failure will result in transcripts that can be recognized by NMD. Confirmation of this hypothesis must await direct experimental validation (e.g., by measuring the rate of retention of IESs in mRNAs from NMD...
Select this article
Research: Unexpectedly low recombination rates and presence of hotspots in termite genomes
- Turid Everitt,
- Tilman Rönneburg,
- Daniel Elsner,
- Anna Olsson,
- Yuanzhen Liu,
- Tuuli Larva,
- Judith Korb,
- and Matthew T. Webster
Genome Res. May 2025 35: 1124-1137; Published in Advance March 20, 2025, doi:10.1101/gr.279180.124
...here suggest that differences in recombination rate between genes with caste-biased patterns of gene expression are mainly because of underlying differences in methylation levels among genes.A direct effect of germline DNA methylation in suppressing recombination could influence variation...

For checked items

view abstracts
download to citation manager

Searching journal content for articles similar to Smeds et al. 26 (9): 1211.

Search Results

Modify Results

This search

Preprint Server

Current Issue

In This Issue

Citation format:
Results / page:
Results order: