Searching journal content for articles similar to Skelly et al. 23 (9): 1496.

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  1. ...differences is costly and challenging. Here, we introduce CRI-15 SPA-Map, a genetic mapping strategy combining CRISPR-Cas9 engineering, selective 16 ploidy ablation (SPA), and high-throughput phenotyping for precise genetic mapping with or 17 without genotyping in the yeast Saccharomyces cerevisiae. In CRI...
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  2. ...quantitative information about the translational states of all transcripts. Riboprofiling has revealed that relative translational rates vary across the transcriptome by ;100-fold in the budding yeast Saccharomyces cerevisiae, contributing substantially to the dynamic range of expression (Ingolia et al. 2009...
  3. ...yeast strains. Phenotypic differentiation between strains varying in population ancestry In 99 of the 100-s strains (excluding the single Malaysian population strain), we tested for phenotypic differences associated with strains with different population ancestries. Of 49 phenotypes, eight showed...
  4. ...Halobacterium salinarum . For yeast, our method correctly identifies known phenotypes for a diversity of genetic backgrounds under cyclohexamide stress and also detects previously unidentified oxidative stress sensitivity across a subset of strains. Together, these results demonstrate that the GP models...
  5. ..., et al. 2013. Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast. Genome Res 23: 1496–1504. Smith EN, Kruglyak L. 2008. Gene-environment interaction in yeast gene expression. PLoS Biol 6: e83. Stoter M, Niederlein A, Barsacchi R, Meyenhofer F, Brandl H...
  6. ...is too vast. One approach to resolve this is to predict candidate modifier interactions between loci, and then to specifically test these for associations with the phenotype. Here, we describe a general method for predicting genetic interactions based on the use of integrated functional gene networks. We...
  7. ...). Finally, there is a rich yeast literature on methods for integrating gene-expression data with molecular networks and pathways, with the goal of identifying network “hot spots” or “expression-activated modules” ( Zien et al. 2000 ; Ge et al. 2001 ; Ideker et al. 2001 , 2002 ; Hanisch et al. 2002...
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  8. ...Caenorhabditis elegans ( Kamath et al. 2003 ) and in the budding yeast Saccharomyces cerevisiae ( Winzeler et al. 1999 ), placing genes into broad functional classes (e.g., fecundity, viability, morphology). These resources for functional information make it feasible to couple phenotypic categorizations...
  9. ...to prevent accumulation of damage in the mother, Hydra cells damaged by mutations may be transmitted via budding to the offspring.In conclusion, the presented first insights into the evolutionary forces that shape the of the nonsenescent H. magnipapillata strain 105 excluded that its exceptional longevity...
  10. ...hardiness, sugar content, flesh color, and bloom date were revealed. Finally, based on 30 yr of observation, a candidate gene associated with bloom date advance, representing peach responses to global warming, was identified. Collectively, our study provides insights into molecular bases of how environments...
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