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  1. ...in the petrous pyramid that will be destroyed through sampling of ancient DNA highlights the importance of being a careful steward of these elements.As part of a search for alternative optimal sources for ancient DNA that can be used in place of the cochlea, we noted that auditory ossicles have similar...
  2. ...for sampling human petrous bones from the cranial base for ancient DNA analysis. BioTechniques 62: 283–289. doi:10.2144/000114558 ↵Sirak K, Fernandes D, Cheronet O, Harney E, Mah M, Mallick S, Rohland N, Adamski N, Broomandkhoshbacht N, Callan K, et al. 2020. Human auditory ossicles as an alternative optimal...
  3. ...takes into account expression variation within cell types without including each pair of individual cells in the model, leading to a highly stable set of marker genes that allow to accurately discriminate between cell types and that can be computed to optimality efficiently.A common first step...
  4. ...-bound instances (4.6-fold enrichment; one example is shown in Fig. 2D). A clear example of an ancient RELA-associated TE was MER81, a 114-bp non-autonomous DNA transposon (Bao et al. 2015). MER81 was enriched for RELA binding in all three species (10.9-fold change in human, 10.6-fold change in mouse, and 6.2-fold...
  5. ...and apologize for any confusion this may have caused.doi: 10.1101/gr.280860.125 Published by Cold Spring Harbor Laboratory Press Corrigendum: Characterization of DNA methylation reader proteins in Arabidopsis thaliana Jonathan Cahn , James P.B. Lloyd , Ino D. Karemaker , Pascal W.T.C. Jansen , Jahnvi Pflueger...
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  6. ...(c.1181G>C, p.R394T), previously identified as a potential mechanism of resistance to T-DXd, because SLX4 encodes a DNA repair protein that regulates structure-specific endonucleases and seems to play a role in resistance to TOP1 inhibition. Among HER2- cell lines, MCF-7 and ZR-75-1 (HR+) and MDA...
  7. ...), as an optimal source of ancient DNA (Gamba et al. 2014; Pinhasi et al. 2015, 2019) is one of the driving factors in this revolution, making it possible to access ancient DNA from geographic regions with climatic conditions unfavorable to ancient DNA preservation. However, accessing this optimal source...
  8. ...-Loeffler-Institut, 17493 Greifswald, Germany; 3School of Health Sciences-Biomedical Sciences Program, Missouri State University, Springfield, Missouri 65897, USA A tightly regulated DNA damage response is critical to the overall integrity of the . Here, we combine transcriptomics and proteomics to study DNA damage...
  9. ...sacrificed for this study. Total genomic DNA was extracted using the Qiagen DNeasy blood and tissue kit and quantified on the Qubit DNA quantification system (Thermo Fisher Scientific) using Qubit broad range assay reagents, following the manufacturer's protocol. DNA concentration across all samples...
  10. ...affinities following from differences in RNA Polymerase II kinetics owing to local GC content.Alternative splicing occurs predominantly cotranscriptionally and thus takes place in close proximity to the DNA from which the transcript originated (Reimer et al. 2021). Beyond being impacted by transcription...
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