Searching journal content for articles similar to Shah et al. 24 (11): 1725.

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  1. Research: Epigenetic drift score captures directional methylation variability and links aging to transcriptional, metabolic, and genetic alterations
    • Xiu Fan,
    • Qili Qian,
    • Wenran Li,
    • Tianzi Liu,
    • Changqing Zeng,
    • Peilin Jia,
    • Huandong Lin,
    • Xin Gao,
    • Li Jin,
    • Mingfeng Xia,
    • Sijia Wang,
    • and Fan Liu
    Genome Res. October 2025 35: 2173-2188; Published in Advance August 1, 2025, doi:10.1101/gr.280155.124
    ...implicating environmental exposures. Infectious agents, such as cytomegalovirus, have also been shown to induce widespread methylation variance in a cell composition-independent manner (Bergstedt et al. 2022). At the chromatin level, drift-CpGs are enriched in repressive Polycomb-bound regions (Slieker et al...
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  2. Research: Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence
    • Lavinia Gordon,
    • Jihoon E. Joo,
    • Joseph E. Powell,
    • Miina Ollikainen,
    • Boris Novakovic,
    • Xin Li,
    • Roberta Andronikos,
    • Mark N. Cruickshank,
    • Karen N. Conneely,
    • Alicia K. Smith,
    • Reid S. Alisch,
    • Ruth Morley,
    • Peter M. Visscher,
    • Jeffrey M. Craig,
    • and Richard Saffery
    Genome Res. August 2012 22: 1395-1406; Published in Advance July 16, 2012, doi:10.1101/gr.136598.111
    ...data and 94 MZ pairs and 17 DZ pairs from Infinium HM27 data sets from a previously published data set (Rakyan et al. 2010), with additional sets of unpublished data (Fig. 4; Table 2). We found no evidence for epigenetic drift throughout the life course in either MZ or DZ pairs. Identification...
  3. Research: Longitudinal linked-read sequencing reveals ecological and evolutionary responses of a human gut microbiome during antibiotic treatment
    • Morteza Roodgar,
    • Benjamin H. Good,
    • Nandita R. Garud,
    • Stephen Martis,
    • Mohan Avula,
    • Wenyu Zhou,
    • Samuel M. Lancaster,
    • Hayan Lee,
    • Afshin Babveyh,
    • Sophia Nesamoney,
    • Katherine S. Pollard,
    • and Michael P. Snyder
    Genome Res. August 2021 31: 1433-1446; Published in Advance July 22, 2021, doi:10.1101/gr.265058.120
    ...or months after antibiotics are removed (Dethlefsen and Relman 2011; Buffie et al. 2015; Ng et al. 2019). This suggests an intriguing hypothesis, in which the long-term composition of a healthy gut community is buffered against brief environmental perturbations.However, the mechanisms that enable...
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