Searching journal content for articles similar to Seplyarskiy et al. 26 (2): 174.

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  1. Research: Human mismatch repair system balances mutation rates between strands by removing more mismatches from the lagging strand
    • Maria A. Andrianova,
    • Georgii A. Bazykin,
    • Sergey I. Nikolaev,
    • and Vladimir B. Seplyarskiy
    Genome Res. August 2017 27: 1336-1343; Published in Advance May 16, 2017, doi:10.1101/gr.219915.116
    ...Biol 17: 31. Seplyarskiy VB, Soldatov RA, Popadin KY, Antonarakis SE, Bazykin GA, Nikolaev SI. 2016. APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication. Genome Res 26: 174–182. Seplyarskiy VB, Andrianova MA, Bazykin GA. 2017. APOBEC3A...
  2. Research: Genetic inhibitors of APOBEC3B-induced mutagenesis
    • Tony M. Mertz,
    • Elizabeth Rice-Reynolds,
    • Ly Nguyen,
    • Anna Wood,
    • Cameron Cordero,
    • Nicholas Bray,
    • Victoria Harcy,
    • Rudri K. Vyas,
    • Debra Mitchell,
    • Kirill Lobachev,
    • and Steven A. Roberts
    Genome Res. September 2023 33: 1568-1581; Published in Advance August 2, 2023, doi:10.1101/gr.277430.122
    ...facilitate HR-dependent lesion bypass of APOBEC-induced DNA damage in breast cancer, we assessed SBS13 mutations for replicative asymmetry associated with deamination of the lagging strand template in the absence of BRCA1 or BRCA2 (Fig. 6C). As previously reported for pan-cancer analysis of APOBEC-induced...
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  3. Research: APOBEC3A/B-induced mutagenesis is responsible for 20% of heritable mutations in the TpCpW context
    • Vladimir B. Seplyarskiy,
    • Maria A. Andrianova,
    • and Georgii A. Bazykin
    Genome Res. February 2017 27: 175-184; Published in Advance December 9, 2016, doi:10.1101/gr.210336.116
    ...by APOBEC3A/B: transcribed regions, recombination hotspots, and expressed transposons. No APOBEC3A/B-specific Figure 1. Mutations in different APOBEC3A/B contexts aremore frequent on the lagging strand (A–D). Horizontal axis indicates the propensity of the region of the DNA strand to be replicated...
  4. Research: APOBEC3A drives deaminase mutagenesis in human gastric epithelium
    • Yohan An,
    • Ji-Hyun Lee,
    • Joonoh Lim,
    • Jeonghwan Youk,
    • Seongyeol Park,
    • Ji-Hyung Park,
    • Kijong Yi,
    • Taewoo Kim,
    • Chang Hyun Nam,
    • Won Hee Lee,
    • Soo A Oh,
    • Yoo Jin Bae,
    • Thomas M. Klompstra,
    • Haeun Lee,
    • Jinju Han,
    • Junehwak Lee,
    • Jung Woo Park,
    • Jie-Hyun Kim,
    • Hyunki Kim,
    • Hugo Snippert,
    • Bon-Kyoung Koo,
    • and Young Seok Ju
    Genome Res. October 2025 35: 2158-2172; Published in Advance August 26, 2025, doi:10.1101/gr.280338.124
    ...APOBEC-induced DNA damage, such as replication stalling or double-strand breaks (DSBs), as previously reported (Fig. 1G,H; Supplemental Fig. S5; Burns et al. 2013; Green et al. 2016).APOBEC3A, not APOBEC3B, induces genomic mutationsTo assess the mutagenic impacts of A3A and A3B, we investigated acquired...
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