Searching journal content for articles similar to Seo et al. 22 (11): 2109.

Displaying results 1-10 of 75

For checked items

view abstracts
download to citation manager

Select this article
Research: Transcriptomic landscape of transposable elements reveals LTR7-PLAAT4 as a potential oncogene and therapeutic target in pancreatic adenocarcinoma
- Meilong Shi,
- Chuanqi Teng,
- Shan Zhang,
- Xiaobo He,
- Lingyun Xu,
- Fengxian Han,
- Rongqi Wen,
- Ganjun Yu,
- Jingwen Liu,
- Yang Feng,
- Yanfeng Wu,
- Yan Ren,
- Gang Jin,
- and Jing Li
Genome Res. February 2026 36: 275-290; Published in Advance January 8, 2026, doi:10.1101/gr.280528.125
...coexpression, potentially fostering tumor progression. On the immunogenic front, HLA-I immunopeptidomics of AsPC-1 cells and DAC13 organoids identify over 11,000 peptides respectively. Althought mutation-derived neoantigens are rare, several peptides are originated from TE-chimeric transcripts, including four...
OPEN ACCESS ARTICLE
Select this article
Method: Gene duplication is associated with gene diversification and potential neofunctionalization in lung cancer evolution
- Paul Ashford,
- Alexander M. Frankell,
- Zofia Piszka,
- Camilla S.M. Pang,
- Mahnaz Abbasian,
- Maise Al Bakir,
- Mariam Jamal-Hanjani,
- Nicholas McGranahan,
- Charles Swanton,
- and Christine A. Orengo
Genome Res. March 2026 36: 561-577; Published in Advance February 19, 2026, doi:10.1101/gr.278663.123
...(Bailey et al. 2018) and prostate cancer (Armenia et al. 2018), indicating that the landscape of oncogenic drivers includes many rarely mutated genes.Although previous studies have analyzed subclonal selection in the lung (Jamal-Hanjani et al. 2017) and other tumor types (Loeb et al. 2019), here we...
OPEN ACCESS ARTICLE
Select this article
Research: Androgen receptor–mediated assisted loading of the glucocorticoid receptor modulates transcriptional responses in prostate cancer cells
- Johannes Hiltunen,
- Laura Helminen,
- Niina Aaltonen,
- Kaisa-Mari Launonen,
- Hanna Laakso,
- Marjo Malinen,
- Einari A. Niskanen,
- Jorma J. Palvimo,
- and Ville Paakinaho
Genome Res. August 2025 35: 1717-1732; Published in Advance June 2, 2025, doi:10.1101/gr.280224.124
...Androgen receptor–mediated assisted loading of the glucocorticoid receptor modulates transcriptional responses in prostate cancer cells Johannes Hiltunen1,3, Laura Helminen1,3, Niina Aaltonen1,3, Kaisa-Mari Launonen1, Hanna Laakso1, Marjo Malinen2, Einari A. Niskanen1, Jorma J. Palvimo1 and Ville...
OPEN ACCESS ARTICLE
Select this article
Resource: Multiscale network modeling reveals the gene regulatory landscape driving cancer prognosis in 32 cancer types
- Peng Xu and
- Bin Zhang
Genome Res. October 2023 33: 1806-1817; Published in Advance October 31, 2023, doi:10.1101/gr.278063.123
...adenocarcinoma (PAAD) was associated with a module related to the TP53 pathway, a key tumor-suppressor pathway that is frequently mutated in cancers. In liver cancer (LIHC), a unique module, M194, was related to xenobiotic metabolism, which is critical for detoxification of foreign substances and may contribute...
OPEN ACCESS ARTICLE
Select this article
Research: Alternative polyadenylation drives oncogenic gene expression in pancreatic ductal adenocarcinoma
- Swati Venkat,
- Arwen A. Tisdale,
- Johann R. Schwarz,
- Abdulrahman A. Alahmari,
- H. Carlo Maurer,
- Kenneth P. Olive,
- Kevin H. Eng,
- and Michael E. Feigin
Genome Res. March 2020 30: 347-360; Published in Advance February 6, 2020, doi:10.1101/gr.257550.119
...reveals APA as an underappreciated driver of protumorigenic gene expression in PDAC via the loss of miRNA regulation.Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a 5-yr survival rate of 9% (Siegel et al. 2017). Extensive sequencing studies have uncovered recurrently mutated genes (KRAS...
OPEN ACCESS ARTICLE
Select this article
Method: A full-proteome, interaction-specific characterization of mutational hotspots across human cancers
- Siwei Chen,
- Yuan Liu,
- Yingying Zhang,
- Shayne D. Wierbowski,
- Steven M. Lipkin,
- Xiaomu Wei,
- and Haiyuan Yu
Genome Res. January 2022 32: 135-149; Published in Advance December 28, 2021, doi:10.1101/gr.275437.121
...therapy to the triple-negative cases that harbor TP53–BCL2L1 interface hotspot mutations.Lastly, we systematically explored the pharmacogenomic landscape of our network-prioritized hotspots. Leveraging drug response profiles of approximately 1000 human cancer cell lines screened with 265 anticancer...
Select this article
Research: Long-read sequencing for non-small-cell lung cancer genomes
- Yoshitaka Sakamoto,
- Liu Xu,
- Masahide Seki,
- Toshiyuki T. Yokoyama,
- Masahiro Kasahara,
- Yukie Kashima,
- Akihiro Ohashi,
- Yoko Shimada,
- Noriko Motoi,
- Katsuya Tsuchihara,
- Susumu S. Kobayashi,
- Takashi Kohno,
- Yuichi Shiraishi,
- Ayako Suzuki,
- and Yutaka Suzuki
Genome Res. September 2020 30: 1243-1257; Published in Advance September 4, 2020, doi:10.1101/gr.261941.120
...relevance of those mutations was further revealed by epi, transcriptome, and protein analyses of the affected signaling pathways. Such structural aberrations were also found in clinical lung adenocarcinoma specimens. Those structural aberrations were unlikely to be reliably detected by conventional short...
OPEN ACCESS ARTICLE
Select this article
Research: KDM1A maintains genome-wide homeostasis of transcriptional enhancers
- Saurabh Agarwal,
- Katherine M. Bonefas,
- Patricia M. Garay,
- Emily Brookes,
- Yumie Murata-Nakamura,
- Robert S. Porter,
- Todd S. Macfarlan,
- Bing Ren,
- and Shigeki Iwase
Genome Res. February 2021 31: 186-197; Published in Advance January 7, 2021, doi:10.1101/gr.234559.118
...and Shilatifard 2014; Vallianatos et al. 2018). Genome-wide identification of potential enhancer elements has been facilitated by profiling (1) binding of pioneer transcription factors (TFs), (2) chromatin accessibility, and (3) patterns of histone modifications (for review, see Ren and Yue 2015). Monomethylation...
Select this article
Research: Identification of a primitive intestinal transcription factor network shared between esophageal adenocarcinoma and its precancerous precursor state
- Connor Rogerson,
- Edward Britton,
- Sarah Withey,
- Neil Hanley,
- Yeng S. Ang,
- and Andrew D. Sharrocks
Genome Res. May 2019 29: 723-736; Published in Advance April 8, 2019, doi:10.1101/gr.243345.118
...networks operational in Barrett's esophagous and EAC.ResultsIdentification of a network of transcription factors active in EACPreviously we used ATAC-seq to profile the open chromatin landscape of EAC cell lines and identified AP-1 as an important transcription factor family in controlling...
OPEN ACCESS ARTICLE
Select this article
Research: A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre- and post-chemotherapy
- Ayesha Noorani,
- Jan Bornschein,
- Andy G. Lynch,
- Maria Secrier,
- Achilleas Achilleos,
- Matthew Eldridge,
- Lawrence Bower,
- Jamie M.J. Weaver,
- Jason Crawte,
- Chin-Ann Ong,
- Nicholas Shannon,
- Shona MacRae,
- Nicola Grehan,
- Barbara Nutzinger,
- Maria O'Donovan,
- Richard Hardwick,
- Simon Tavaré,
- Rebecca C. Fitzgerald,
- and on behalf of the Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium
Genome Res. June 2017 27: 902-912; Published in Advance May 2, 2017, doi:10.1101/gr.214296.116
...’s Hospital, Cambridge CB2 0QQ, United Kingdom The scientific community has avoided using tissue samples from patients that have been exposed to systemic chemotherapy to infer the genomic landscape of a given cancer. Esophageal adenocarcinoma is a heterogeneous, chemoresistant tumor for which the availability...
OPEN ACCESS ARTICLE

For checked items

view abstracts
download to citation manager

Searching journal content for articles similar to Seo et al. 22 (11): 2109.

Search Results

Modify Results

This search

Preprint Server

Current Issue

In This Issue

Citation format:
Results / page:
Results order: