Searching journal content for articles similar to Schimenti and Bucan 8 (7): 698.

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  1. LETTER: Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations
    • Lawriston Wilson,
    • Yung-Hao Ching,
    • Michael Farias,
    • Suzanne A. Hartford,
    • Gareth Howell,
    • Hongguang Shao,
    • Maja Bucan,
    • and John C. Schimenti
    Genome Res. August 2005 15: 1095-1105; Published in Advance July 15, 2005, doi:10.1101/gr.3826505
    ...have facilitated positional cloning. There are two basic ENU mutagenesis paradigms, -wide and regional. Genome-wide screens can be conducted for both dominant and recessive mutations. For -wide recessive screens, three generations of breeding are required to produce animals (or embryos) homozygous...
  2. Method: Large-scale identification of chemically induced mutations in Drosophila melanogaster
    • Nele A. Haelterman,
    • Lichun Jiang,
    • Yumei Li,
    • Vafa Bayat,
    • Hector Sandoval,
    • Berrak Ugur,
    • Kai Li Tan,
    • Ke Zhang,
    • Danqing Bei,
    • Bo Xiong,
    • Wu-Lin Charng,
    • Theodore Busby,
    • Adeel Jawaid,
    • Gabriela David,
    • Manish Jaiswal,
    • Koen J.T. Venken,
    • Shinya Yamamoto,
    • Rui Chen,
    • and Hugo J. Bellen
    Genome Res. October 2014 24: 1707-1718; Published in Advance September 25, 2014, doi:10.1101/gr.174615.114
    ...mutagenesis screen, for essential genes on the Drosophila X chromosome and describe strategies to reduce the number of candidate mutations from an average of ∼3500 to 35 single-nucleotide variants per chromosome. By combining WGS with a rough mapping method based on large duplications, we were able to map...
  3. Research: Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity
    • Nan Cher Yeo,
    • Caitlin C. O’Meara,
    • Jason A. Bonomo,
    • Kerry N. Veth,
    • Ritu Tomar,
    • Michael J. Flister,
    • Iain A. Drummond,
    • Donald W. Bowden,
    • Barry I. Freedman,
    • Jozef Lazar,
    • Brian A. Link,
    • and Howard J. Jacob
    Genome Res. January 2015 25: 57-65; Published in Advance October 1, 2014, doi:10.1101/gr.182881.114
    ...filtration barrier. Using congenic rats, we showed that a locus containing the Shroom3 gene modifies the risk of developing renal impairments. The congenic region contains 60 known and 43 predicted genes, some of which may also affect renal phenotypes. Based on sequence data, Shroom3 appears to be the most...
  4. Method: MMAPPR: Mutation Mapping Analysis Pipeline for Pooled RNA-seq
    • Jonathon T. Hill,
    • Bradley L. Demarest,
    • Brent W. Bisgrove,
    • Bushra Gorsi,
    • Yi-Chu Su,
    • and H. Joseph Yost
    Genome Res. April 2013 23: 687-697; Published in Advance January 8, 2013, doi:10.1101/gr.146936.112
    ...known mutants, nkx2.5 (KV Targoff, unpubl.) and tbx1 (Piotrowski et al. 2003), and two unknown mutant lines, zy13 and zy14, identified in an ENU screen performed in our laboratory. MMAPPR was then used to identify a genomic region containing the mutation and generate a list of nonsynonymous mutations...
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  5. Research: Genomic basis of endosymbiont-conferred protection against an insect parasitoid
    • Allison K. Hansen,
    • Christoph Vorburger,
    • and Nancy A. Moran
    Genome Res. January 2012 22: 106-114; Published in Advance September 23, 2011, doi:10.1101/gr.125351.111
    ...parasitoids, minus signs indicate a nonprotective phenotype, and ‘‘unk’’ indicates unknown phenotype, based on previous studies (Oliver et al. 2003, 2009; Vorburger et al. 2010) and this study. Genomic basis of endosymbiont protection Genome Research 111 www..org Methods Parasitism trials In order to compare...
  6. METHODS: Interdigitated Deletion Complexes on Mouse Chromosome 5 Induced by Irradiation of Embryonic Stem Cells
    • John C. Schimenti,
    • Brian J. Libby,
    • Rebecca A. Bergstrom,
    • Lawriston A. Wilson,
    • Dieter Naf,
    • Lisa M. Tarantino,
    • Alireza Alavizadeh,
    • Andreas Lengeling,
    • and Maja Bucan
    Genome Res. July 1, 2000 10: 1043-1050; doi:10.1101/gr.10.7.1043
    .... , Montgomery C. , Raymer G. ( 1982 ) Analysis of the albino-locus region of the mouse. IV. Characterization of 34 deficiencies. Genetics 100 : 427 – 453 . ↵ Schimenti J. , Bucan M. ( 1998 ) Functional genomics in the mouse: Phenotype-based mutagenesis screens. Genome Res. 8 : 698 – 710 . ↵ Schumacher A...
  7. LETTER: A Major Effect QTL Determined by Multiple Genes in Epileptic EL Mice
    • Marie E. Legare,
    • Frederick S. Bartlett II,
    • and Wayne N. Frankel
    Genome Res. January 1, 2000 10: 42-48; doi:10.1101/gr.10.1.42
    ...mapping in EL mice. J. Neurogenet. 12 : 67 – 86 . ↵ Rise M.L. , Coffin J.M. , Frankel W.N. , Seyfried T.N. ( 1991 ) Genes for epilepsy mapped in the mouse. Science 253 : 669 – 673 . ↵ Schimenti J. , Bucan M. ( 1998 ) Functional genomics in the mouse: Phenotype-based mutagenesis screens. Genome Res. 8...
  8. REVIEW: A Phenotype Map of the Mouse X Chromosome: Models for Human X-linked Disease
    • Yvonne Boyd,
    • Helen J. Blair,
    • Pamela Cunliffe,
    • Walter K. Masson,
    • and Vivienne Reed
    Genome Res. March 1, 2000 10: 277-292; doi:10.1101/gr.10.3.277
    ...to the mouse as a model system for this phase of the genome project. Mouse mutants have long been used as a means of investigating gene function and disease pathogenesis, and recently, several large mutagenesis programs have been initiated to fulfill the burgeoning demand of functional genomics research...
  9. LETTER: Identification of the Modifier of Min 2 (Mom2) Locus, a New Mutation That Influences Apc-Induced Intestinal Neoplasia
    • Karen A. Silverman,
    • Revati Koratkar,
    • Linda D. Siracusa,
    • and Arthur M. Buchberg
    Genome Res. January 1, 2002 12: 88-97; doi:10.1101/gr.206002
    ...extensively studied is the Min (multiple intestinal neoplasia) mouse model, which was discovered through phenotypic screening following ENU mutagenesis ( Moser et al. 1990 ). Min mice carry a dominant, fully penetrant mutation in the Apc gene, which results in the development of multiple adenomas throughout...
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