Searching journal content for articles similar to Satija and Bradley 22 (4): 656.

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  1. Research: Zelda is differentially required for chromatin accessibility, transcription factor binding, and gene expression in the early Drosophila embryo
    • Katharine N. Schulz,
    • Eliana R. Bondra,
    • Arbel Moshe,
    • Jacqueline E. Villalta,
    • Jason D. Lieb,
    • Tommy Kaplan,
    • Daniel J. McKay,
    • and Melissa M. Harrison
    Genome Res. November 2015 25: 1715-1726; Published in Advance September 2, 2015, doi:10.1101/gr.192682.115
    ...transcriptionally quiescent and undergoes significant chromatin remodeling. In Drosophila, the DNA-binding protein Zelda (also known as Vielfaltig) is required for this transition and for transcriptional activation of the zygotic . Open chromatin is associated with Zelda-bound loci, as well as more generally...
  2. Research: ATAC-seq reveals regional differences in enhancer accessibility during the establishment of spatial coordinates in the Drosophila blastoderm
    • Marta Bozek,
    • Roberto Cortini,
    • Andrea Ennio Storti,
    • Ulrich Unnerstall,
    • Ulrike Gaul,
    • and Nicolas Gompel
    Genome Res. May 2019 29: 771-783; Published in Advance April 8, 2019, doi:10.1101/gr.242362.118
    ...-Martinsried, Germany Corresponding author: gompel@bio.lmu.deAbstractEstablishment of spatial coordinates during Drosophila embryogenesis relies on differential regulatory activity of axis patterning enhancers. Concentration gradients of activator and repressor transcription factors (TFs) provide positional information...
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  3. Research: Zelda overcomes the high intrinsic nucleosome barrier at enhancers during Drosophila zygotic genome activation
    • Yujia Sun,
    • Chung-Yi Nien,
    • Kai Chen,
    • Hsiao-Yun Liu,
    • Jeff Johnston,
    • Julia Zeitlinger,
    • and Christine Rushlow
    Genome Res. November 2015 25: 1703-1714; Published in Advance September 2, 2015, doi:10.1101/gr.192542.115
    ...motifs embedded in nucleosomes, Zld’s ability to reduce nucleosome occupancy and facilitate the binding of TFs certainly fulfills a pioneering role. The pioneering role we presented here for Zld during Drosophila ZGAmay be a general feature of key zygotic activators. For example, Pou5f3, which controls...
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  4. Method: Uncovering cis-regulatory sequence requirements for context-specific transcription factor binding
    • J. Omar Yáñez-Cuna,
    • Huy Q. Dinh,
    • Evgeny Z. Kvon,
    • Daria Shlyueva,
    • and Alexander Stark
    Genome Res. October 2012 22: 2018-2030; Published in Advance April 25, 2012, doi:10.1101/gr.132811.111
    ...requirements for individual binding sites and validate them experimentally by motif-disrupting mutations. This identifies the TAGteam motif of the TF Vielfaltig (VFL; also known as Zelda) to be a key determinant of Twist binding and enhancer activity in the early Drosophila embryo. We also show that knowledge...
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