Searching journal content for articles similar to Sanford et al. 19 (3): 381.

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  1. Method: A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1
    • Dror Hollander,
    • Maya Donyo,
    • Nir Atias,
    • Keren Mekahel,
    • Zeev Melamed,
    • Sivan Yannai,
    • Galit Lev-Maor,
    • Asaf Shilo,
    • Schraga Schwartz,
    • Iris Barshack,
    • Roded Sharan,
    • and Gil Ast
    Genome Res. April 2016 26: 541-553; Published in Advance February 9, 2016, doi:10.1101/gr.193169.115
    ...material is available for this article.] Alternative splicing is an evolutionarily conserved mechanism that increases transcriptomic and proteomic diversity by allowing the generation of multiple mRNA products from a single gene. It is highly prevalent as >95%of humanmultiexonic genes undergo alternative...
  2. Method: Quantitative evaluation of all hexamers as exonic splicing elements
    • Shengdong Ke,
    • Shulian Shang,
    • Sergey M. Kalachikov,
    • Irina Morozova,
    • Lin Yu,
    • James J. Russo,
    • Jingyue Ju,
    • and Lawrence A. Chasin
    Genome Res. August 2011 21: 1360-1374; Published in Advance June 9, 2011, doi:10.1101/gr.119628.110
    ...of the splicing impact of a complete set of RNA 6-mer sequences by deep sequencing successfully spliced transcripts. All 4096 6-mers were substituted at five positions within two different internal exons in a 3-exon minigene, and millions of successfully spliced transcripts were sequenced after transfection...
  3. Research: Loss of exon identity is a common mechanism of human inherited disease
    • Timothy Sterne-Weiler,
    • Jonathan Howard,
    • Matthew Mort,
    • David N. Cooper,
    • and Jeremy R. Sanford
    Genome Res. October 2011 21: 1563-1571; Published in Advance July 12, 2011, doi:10.1101/gr.118638.110
    ...different inherited disease mutations in 67 different disease genes. Taken together, we find that ∼25% (7154/27,681) of known mis-sense and nonsense disease-causing mutations alter functional splicing signals within exons, suggesting a much more widespread role for aberrant mRNA processing in causing human...
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