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Research: Individualized VDJ recombination predisposes the available Ig sequence space
- Andrei Slabodkin,
- Maria Chernigovskaya,
- Ivana Mikocziova,
- Rahmad Akbar,
- Lonneke Scheffer,
- Milena Pavlović,
- Habib Bashour,
- Igor Snapkov,
- Brij Bhushan Mehta,
- Cédric R. Weber,
- Jose Gutierrez-Marcos,
- Ludvig M. Sollid,
- Ingrid Hobæk Haff,
- Geir Kjetil Sandve,
- Philippe A. Robert,
- and Victor Greiff
Genome Res. December 2021 31: 2209-2224; Published in Advance November 23, 2021, doi:10.1101/gr.275373.121
...models. This suggests that, in addition to genetic, there is also nongenetic modulation of VDJ recombination. We demonstrate that population-wide individualized VDJ recombination can result in orders of magnitude of difference in the probability to generate (auto)antigen-specific Ig sequences. Our...
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Method: Gene prediction in the immunoglobulin loci
- Vikram Sirupurapu,
- Yana Safonova,
- and Pavel A. Pevzner
Genome Res. June 2022 32: 1152-1169; Published in Advance May 11, 2022, doi:10.1101/gr.276676.122
...LAAELLYCR and the sloth gene “sloth_38” with suffix CVLLCE (Supplemental Fig. S5). The only other known V gene with a long noncanonical suffix is the cow gene IGHV1-7, which plays a special role in generating ultralong CDR3s by recombining with the longest known D gene (IGHD8-2) of length 148 nt (Wang et al...

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