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Rossini et al. 36 (1): 20
.
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Method
:
A novel multislice framework for precision 3D spatial domain reconstruction and disease pathology analysis
Daijun Zhang
,
Ren Qi
,
Xun Lan
,
and
Bin Liu
Genome Res.
August 2025
35
:
1794
-
1808
;
Published in Advance
July 14, 2025
,
doi:
10.1101/gr.280281.124
...-dependent interactions, offers unique advantages in anatomically characterizing and delineating intra-tumor heterogeneity. We applied STMSC to human
breast
cancer data acquired via the 10x
Genomics
Visium platform. Noted for its marked intra- and intertumoral heterogeneity, the data set was annotated into 20 spatial...
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Method
:
FocalSV enables target region–based structural variant assembly and refinement using single-molecule long-read sequencing data
Can Luo
,
Zimeng Jamie Zhou
,
Yichen Henry Liu
,
and
Xin Maizie Zhou
Genome Res.
October 2025
35
:
2252
-
2272
;
Published in Advance
August 13, 2025
,
doi:
10.1101/gr.280282.124
...significant potential for advancing precision medicine. Despite notable
progress
in single-molecule long-read sequencing technologies, accurately identifying SV breakpoints and resolving their sequence remains a major challenge. Current alignment-based tools often struggle with precise breakpoint detection...
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ARTICLE
:
Toward the development of a gene index to the human genome: an assessment of the nature of high-throughput EST sequence data.
J S Aaronson
,
B Eckman
,
R A Blevins
,
J A Borkowski
,
J Myerson
,
S Imran
,
and
K O Elliston
Genome Res.
September 1996
6
:
829
-
845
;
doi:
10.1101/gr.6.9.829
...Toward the development of a gene index to the human
genome
: an assessment of the nature of high-throughput EST sequence data. J S Aaronson , B Eckman , R A Blevins , J A Borkowski , J Myerson , S Imran and K O Elliston...
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Research
:
Genomic and transcriptomic plasticity in treatment-naïve ovarian cancer
Marlous Hoogstraat
,
Mirjam S. de Pagter
,
Geert A. Cirkel
,
Markus J. van Roosmalen
,
Timothy T. Harkins
,
Karen Duran
,
Jennifer Kreeftmeijer
,
Ivo Renkens
,
Petronella O. Witteveen
,
Clarence C. Lee
,
Isaac J. Nijman
,
Tanisha Guy
,
Ruben van ’t Slot
,
Trudy N. Jonges
,
Martijn P. Lolkema
,
Marco J. Koudijs
,
Ronald P. Zweemer
,
Emile E. Voest
,
Edwin Cuppen
,
and
Wigard P. Kloosterman
Genome Res.
February 2014
24
:
200
-
211
;
Published in Advance
November 12, 2013
,
doi:
10.1101/gr.161026.113
...from the same patient. Finally, we took advantage of the
multilevel
tumor analysis to understand the effects of
genomic
breakpoints on qualitative and quantitative gene expression changes. We show that intra-tumor gene expression differences are caused by site-specific
genomic
alterations, including...
Abstract
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Review
:
Advancements in prospective single-cell lineage barcoding and their applications in research
Xiaoli Zhang
,
Yirui Huang
,
Yajing Yang
,
Qi-En Wang
,
and
Lang Li
Genome Res.
December 2024
34
:
2147
-
2162
;
Published in Advance
November 21, 2024
,
doi:
10.1101/gr.278944.124
...of individual cells has been a crucial pursuit in understanding the process of
organ
and tissue formation, as well as the
progression
of diseases. A profound exploration into the molecular mechanisms dictating cell differentiation,
organization
, fate, and function has long been the focus point within the fields...
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