Searching journal content for articles similar to Robinson et al. 24 (2): 340.

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  1. Resource: GenomeMUSter mouse genetic variation service enables multitrait, multipopulation data integration and analysis
    • Robyn L. Ball,
    • Molly A. Bogue,
    • Hongping Liang,
    • Anuj Srivastava,
    • David G. Ashbrook,
    • Anna Lamoureux,
    • Matthew W. Gerring,
    • Alexander S. Hatoum,
    • Matthew J. Kim,
    • Hao He,
    • Jake Emerson,
    • Alexander K. Berger,
    • David O. Walton,
    • Keith Sheppard,
    • Baha El Kassaby,
    • Francisco Castellanos,
    • Govindarajan Kunde-Ramamoorthy,
    • Lu Lu,
    • John Bluis,
    • Sejal Desai,
    • Beth A. Sundberg,
    • Gary Peltz,
    • Zhuoqing Fang,
    • Gary A. Churchill,
    • Robert W. Williams,
    • Arpana Agrawal,
    • Carol J. Bult,
    • Vivek M. Philip,
    • and Elissa J. Chesler
    Genome Res. January 2024 34: 145-159; Published in Advance January 30, 2024, doi:10.1101/gr.278157.123
    ...multitrait, multipopulation meta-analysis. We show this in cross-species comparisons of type 2 diabetes and substance use disorder meta-analyses, leveraging mouse data to characterize the likely role of human variant effects in disease. Other applications include refinement of mapped loci and prioritization...
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  2. Mini-Review: Large-scale genomic analysis of the domestic dog informs biological discovery
    • Reuben M. Buckley and
    • Elaine A. Ostrander
    Genome Res. June 2024 34: 811-821; Published in Advance July 2, 2024, doi:10.1101/gr.278569.123
    ...of cellular heterogeneity within the sample. Single-cell profiling of open chromatin in trait-relevant tissues and developmental time points will help prioritize variants with phenotypic impacts as well as disease and trait-relevant cell types (Corces et al. 2020; Son et al. 2023).The future of canine...
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  3. Research: Somatic structural variation targets neurodevelopmental genes and identifies SHANK2 as a tumor suppressor in neuroblastoma
    • Gonzalo Lopez,
    • Karina L. Conkrite,
    • Miriam Doepner,
    • Komal S. Rathi,
    • Apexa Modi,
    • Zalman Vaksman,
    • Lance M. Farra,
    • Eric Hyson,
    • Moataz Noureddine,
    • Jun S. Wei,
    • Malcolm A. Smith,
    • Shahab Asgharzadeh,
    • Robert C. Seeger,
    • Javed Khan,
    • Jaime Guidry Auvil,
    • Daniela S. Gerhard,
    • John M. Maris,
    • and Sharon J. Diskin
    Genome Res. September 2020 30: 1228-1242; Published in Advance August 13, 2020, doi:10.1101/gr.252106.119
    ..., with a median age at diagnosis of 17 mo (Maris 2010). Approximately 50% of cases present with disseminated disease at the time of diagnosis. Despite intense multimodal therapy, the survival rate for this high-risk subset remains <50% (Maris 2010). Recent whole- and exome sequencing studies of neuroblastoma have...
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