Searching journal content for articles similar to Rivera-Mulia et al. 25 (8): 1091.

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  1. ...-stimulated primary aortic endothelial cells isolated from human, mouse, and cow, we find that 55 TE subfamilies are associated with RELA-bound regions, many of which reside near TNF-responsive genes. A prominent example of lineage-specific contribution of transposons comes from the bovine SINE subfamilies Bov-tA1...
  2. ...through the precise regulation of histone acetylation patterns.Embryonic stem cells (ESCs) are widely used to study the transcriptional networks required for pluripotency and tissue-specific differentiation in early embryos (for review, see Martello and Smith 2014). We have previously shown an essential...
  3. ...are largely unknown. Here, we profile -wide changes to gene expression and chromatin structure in cardiomyocytes derived from human pluripotent stem cells. We identify and characterize a gene regulatory element essential for regulating MYH6 expression, which encodes human fetal myosin. Using chromatin...
  4. ...RNAs were not included in the network construction because our goal was to identify miRNAs that are specifically induced at the time of diapause entry and their putative target genes. Besides, only down-regulated direct targets were considered before filtering (Supplemental Fig. S6F), to focus on the subset...
  5. ...introduced a new approach to construct gene regulatory networks, exploiting the dynamic changes in DNA RT during lineage specification. RT is cell-type–specific (Hiratani et al. 2010; Ryba et al. 2011; Rivera-Mulia et al. 2015); regulation of RT is critical to maintain stability (Donley et al. 2013; Neelsen...
  6. ...Xist nuclei, it intrigued us to explore the status of X-linked gene silencing on the inactive X. For this, we performed allele-specific RNA-seq analysis for the WT clones, WT EV clones, D1 ΔXp, and D3 ΔXpΔXm XEN cells. As expected, both in WT clones and WT EV clones, X-linked genes showed exclusive...
  7. ...or nuclei and bioinformatic platforms that leverage the power of these data to elucidate regulatory processes have only recently been developed (Reyes et al. 2019; Eisenstein 2020; Chen et al. 2023; Lee et al. 2023; Zhang et al. 2024). Gene expression dynamics, which mediate the biosynthetic tissue...
  8. ...Kenna et al. 2016; Sawai et al. 2016; Säwén et al. 2016). At the same time, because genetic lineage tracing is not feasible in humans, effective strategies for identifying and defining markers capable of capturing both progenitor and stem cell lineages in human populations remain to be developed...
  9. ...Allele-specific control of replication timing and organization during development Juan Carlos Rivera-Mulia1, Andrew Dimond2, Daniel Vera3, Claudia Trevilla-Garcia1, Takayo Sasaki1, Jared Zimmerman1, Catherine Dupont4, Joost Gribnau4, Peter Fraser1,2,3 and David M. Gilbert1,3 1Department...
  10. ...pseudotime. We identified genetic variants regulating gene expression mean and variability, including treatment-specific effects, and showed widespread genetic regulation of the transcriptional dynamics of the gene expression response.The immune system exerts its function through a delicate and timely...
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