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Method: Early embryonic mutations reveal dynamics of somatic and germ cell lineages in mice
- Arikuni Uchimura,
- Hirotaka Matsumoto,
- Yasunari Satoh,
- Yohei Minakuchi,
- Sayaka Wakayama,
- Teruhiko Wakayama,
- Mayumi Higuchi,
- Masakazu Hashimoto,
- Ryutaro Fukumura,
- Atsushi Toyoda,
- Yoichi Gondo,
- and Takeshi Yagi
Genome Res. May 2022 32: 945-955; Published in Advance May 9, 2022, doi:10.1101/gr.276363.121
...(de novo mutations accumulated in long-term breeding mouse lines) (see Supplemental Fig. S8), and somatic mutations (de novo mutations accumulated in ntES cell lines derived from mouse tail fibroblasts) (see Supplemental Fig. S7). (C) Hierarchical clustering of the mutation signatures. Human germline...
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Research: Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers
- Bettina Meier,
- Nadezda V. Volkova,
- Ye Hong,
- Pieta Schofield,
- Peter J. Campbell,
- Moritz Gerstung,
- and Anton Gartner
Genome Res. May 2018 28: 666-675; Published in Advance April 10, 2018, doi:10.1101/gr.226845.117
...(Alexandrov et al. 2013a,b). It is not clear whether these MMR signatures are conserved across evolution and how they reflect MMR defects. Therefore, MMR signatures deduced from defined monogenic MMR-defective backgrounds (which we will herein refer to as mutational patterns) could contribute...
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