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  1. ...accurate correlation between predictions and observation (Fig. 2A), comparable with neural network models based on large amounts of sequence data (Agarwal and Shendure 2020). Prediction accuracy was robust to promoter subtypes (CpG island [CGI] promoters and non-CGI promoters) and was applicable across...
  2. ...contained fewer CpGs and were embedded in regions poor in CpG content when compared with Alu repeats with stable methylation in the tumor ( Fig. 2 A; Supplemental Table S7 ). Another striking feature of Alu repeats unmethylated in all tissues was their proximity to transcription start sites (TSS) and CpG...
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