Searching journal content for articles similar to Reiter et al. 33 (3): 346.

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  1. ...of functional enhancer sequences from three different Drosophila cell lines. We find that the enhancers display distinct cis-regulatory sequence signatures, which are predictive of the enhancers’ cell type-specific or broad activities. These signatures contain transcription factor motifs and a novel class...
  2. ...a comprehensive APA atlas for 261 cell types across 19 porcine tissues based on single-nucleus RNA sequencing (snRNA-seq) data. This analysis reveals tissue- and cell type–specific patterns of APA. We find that many genes display a clear correlation between the average length of 3′ untranslated regions (3′ UTRs...
  3. ...biological contexts. Finally, biological analyses on PBMC data sets demonstrate PRISM-GRN's potential to facilitate the identification of cell type–specific or context-specific GRNs across broader real-world biological research applications. Overall, PRISM-GRN provides a novel paradigm for precise, robust...
  4. ...networks. Central genes in consensus networks are enriched for evolutionarily constrained genes and ubiquitous biological pathways, whereas context-specific central nodes include tissue-specific transcription factors. The increased statistical power from data aggregation facilitates the derivation...
  5. ...for markers of regulatory activity, such as initiating POLR2 binding, DNase I hypersensitivity, active histone marks, and strong activity in enhancer reporter assays conducted in transgenic mouse embryos. These studies also showed that context-specific HOT loci are generated in association with cell...
  6. ...or flexible billboards? J Cell Biochem 94: 890–898. ↵Arnosti DN, Barolo S, Levine M, Small S. 1996. The eve stripe 2 enhancer employs multiple modes of transcriptional synergy. Development 122: 205–214. ↵Bates DM, Watts DG. 1988. Nonlinear regression analysis and its applications. John Wiley & Sons, New York...
  7. ...that the lncRNA locus is nonfunctional or dispensable (or highly context specific in function). As an example, for the well-conserved lncRNA C130071C03Rik (the mouse ortholog of human LINC00461), whole-gene ablation was found not to have a function (Oliver et al. 2014). Yet it is important to consider...
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