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  1. ...in Leishmania Genome Research 2135 www..org In summary, these data lead us to hypothesize that Leishmania might increase mRNA levels in the absence of regulated promoter activity using two mechanisms: first, via gene duplications on disomic chromosomes, which can result in the generation of multicopy arrays...
  2. ...experimental conditions, such as gene knockouts (Cruz et al. 1993) or induced in vitro drug resistance (Ubeda et al. 2008; Leprohon et al. 2009a). Aneuploidy has previously been observed in seven L. major chromosomes from individual parasite cells of a laboratory strain using FISH (Sterkers et al. 2010...
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