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METHODS: A Scalable High-Throughput Chemical Synthesizer
- Eric A. Livesay,
- Ying-Horng Liu,
- Kevin J. Luebke,
- Joel Irick,
- Yuri Belosludtsev,
- Simon Rayner,
- Robert Balog,
- and Stephen Albert Johnston
Genome Res. December 1, 2002 12: 1950-1960; doi:10.1101/gr.359002
...[ Lashkari et al. 1995 (AMOS); Rayner et al. 1998 (MerMade)]. To increase the throughput of this design, the total number of wells in the plate can be increased. However, this leads to an increase in the total number of movements (and thus total synthesis time) needed to position each well below the delivery...
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REVIEW: Automation for Genomics, Part One: Preparation for Sequencing
- Deirdre Meldrum
Genome Res. August 1, 2000 10: 1081-1092; doi:10.1101/gr.101400
...-deck for a throughput of 600 sequence reactions in 8 hr or up to 12 PCR plates unattended. To prevent cross contamination in the RoboAmp 4200, every vessel on the work surface is closed with airtight individual seals. Opening and closing of the special vessels takes place automatically with a novel sealing mechanism...

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