Searching journal content for articles similar to Radke et al. 31 (6): 935.

Displaying results 1-8 of 8

For checked items

view abstracts
download to citation manager

Select this article
Resource: An integrative TAD catalog in lymphoblastoid cell lines discloses the functional impact of deletions and insertions in human genomes
- Chong Li,
- Marc Jan Bonder,
- Sabriya Syed,
- Matthew Jensen,
- Human Genome Structural Variation Consortium (HGSVC),
- HGSVC Functional Analysis Working Group,
- Mark B. Gerstein,
- Michael C. Zody,
- Mark J.P. Chaisson,
- Michael E. Talkowski,
- Tobias Marschall,
- Jan O. Korbel,
- Evan E. Eichler,
- Charles Lee,
- and Xinghua Shi
Genome Res. December 2024 34: 2304-2318; Published in Advance December 5, 2024, doi:10.1101/gr.279419.124
...purifying natural selection to maintain the integrity of the loop (Radke et al. 2021). We examined this hypothesis in our PanGenie data set to assess whether deletions have a depletion effect on the loop anchor loci. We thus intersected all the deletions from the PanGenie genotyped SV calls with our...
Select this article
Research: Mapping multitissue regulatory variants reveals a liver-centric coexpression network associated with duck egg-laying performance
- Yang Xi,
- Jingjing Qi,
- Zhao Yang,
- Yutian Zeng,
- Huicong Zhang,
- Qiuyu Tao,
- Mengru Xu,
- Anqi Huang,
- Shenqiang Hu,
- Chunchun Han,
- Lili Bai,
- Jiwei Hu,
- Jiwen Wang,
- Liang Li,
- Lingzhao Fang,
- and Hehe Liu
Genome Res. October 2025 35: 2211-2225; Published in Advance September 10, 2025, doi:10.1101/gr.280345.124
...of the genetic regulatory landscape.The tissue-specific causal regulatory effects of ABCG2 on duck eggshell colorOur GWAS analysis identified four independent loci located on Chromosome 4 (Chr 4) associated with duck eggshell reflectance in the current population, including the previously reported causal gene...
Select this article
Research: Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity
- Hunter B. Fraser,
- Sasha Levy,
- Arun Chavan,
- Hiral B. Shah,
- J. Christian Perez,
- Yiqi Zhou,
- Mark L. Siegal,
- and Himanshu Sinha
Genome Res. October 2012 22: 1930-1939; Published in Advance May 29, 2012, doi:10.1101/gr.134080.111
...also detected pleiotropic effects of these adaptations on a wide range of morphological traits, which appear to have been mitigated by compensatory mutations at other loci. These results suggest that cis-regulatory adaptation can occur at the level of physically interacting modules and that one...
Select this article
Resource: Assembly of a pangenome for global cattle reveals missing sequences and novel structural variations, providing new insights into their diversity and evolutionary history
- Yang Zhou,
- Lv Yang,
- Xiaotao Han,
- Jiazheng Han,
- Yan Hu,
- Fan Li,
- Han Xia,
- Lingwei Peng,
- Clarissa Boschiero,
- Benjamin D. Rosen,
- Derek M. Bickhart,
- Shujun Zhang,
- Aizhen Guo,
- Curtis P. Van Tassell,
- Timothy P.L. Smith,
- Liguo Yang,
- and George E. Liu
Genome Res. August 2022 32: 1585-1601; Published in Advance August 17, 2022, doi:10.1101/gr.276550.122
...homologous recombination, which produces more deletions than duplications (Turner et al. 2008).SV cluster and SV desert regions were identified among the cattle populations. A significant underrepresentation of SVs in genic regions and regulatory elements was found, implying negative selection against SV...
Select this article
Research: Reactivation of transposable elements following hybridization in fission yeast
- Sergio Tusso,
- Fang Suo,
- Yue Liang,
- Li-Lin Du,
- and Jochen B.W. Wolf
Genome Res. February 2022 32: 324-336; Published in Advance December 14, 2021, doi:10.1101/gr.276056.121
..., in particular, full-length elements carry signatures of purifying selection indicating effective removal by the host. Consistent with reactivation upon hybridization, the number of full-length LTR retrotransposons, varying extensively from zero to 87 among strains, significantly increases with the degree...
Select this article
LETTER: Molecular Correlates of Genes Exhibiting RNAi Phenotypes in Caenorhabditis elegans
- Asher D. Cutter,
- Bret A. Payseur,
- Tovah Salcedo,
- Anne M. Estes,
- Jeffrey M. Good,
- Elizabeth Wood,
- Thomas Hartl,
- Heather Maughan,
- Jannine Strempel,
- Baomin Wang,
- Anthony C. Bryan,
- and Melissa Dellos
Genome Res. December 2003 13: 2651-2657; doi:10.1101/gr.1659203
...in nature. This suggests that loci identified by RNAi would experience stronger purifying selection than other loci, because most non-neutral mutations are deleterious ( Kimura 1983 ), consistent with our finding that loci exhibiting an RNAi phenotype in C. elegans have a lower K A ( Fig. 1 ). Expression...
Select this article
Method: Nematode gene annotation by machine-learning-assisted proteotranscriptomics enables proteome-wide evolutionary analysis
- Alejandro Ceron-Noriega,
- Miguel V. Almeida,
- Michal Levin,
- and Falk Butter
Genome Res. January 2023 33: 112-128; Published in Advance January 18, 2023, doi:10.1101/gr.277070.122
...species. Signals of positive selection in individual ribosomal proteins have been previously detected in different organisms (Yednock and Neigel 2014). We here show in a systematic manner that adaptation might in many cases happen at fundamental gene regulatory levels rather than in very specific...
Select this article
Perspective: Human genomic disease variants: A neutral evolutionary explanation
- Joel T. Dudley,
- Yuseob Kim,
- Li Liu,
- Glenn J. Markov,
- Kristyn Gerold,
- Rong Chen,
- Atul J. Butte,
- and Sudhir Kumar
Genome Res. August 2012 22: 1383-1394; Published in Advance June 4, 2012, doi:10.1101/gr.133702.111
...that are consistent with the neutral theory of molecular evolution. (A) Proportions of single nucleotide variants (SNVs) with a rejected substitution (RS) score greater than 3 in coding and noncoding regions (Goode et al. 2010). A lower degree of genetic variation is permitted by purifying selection in functionally...

For checked items

view abstracts
download to citation manager

Searching journal content for articles similar to Radke et al. 31 (6): 935.

Search Results

Modify Results

This search

Preprint Server

Current Issue

In This Issue

Citation format:
Results / page:
Results order: