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  1. ...neutral, whereas losses of operons and SL2 trans-splicing are extremely deleterious, because the downstream genes in operons have lost promoters (Lawrence 1999; Nimmo and Woollard 2002; Blumenthal 2004). Based on this idea, we previously proposed a quantitative model called “easy come, slow go” to explain...
  2. ...(Vandenberghe et al. 2001). In C. elegans, operons were first observed by Blumenthal and colleagues (Spieth et al. 1993). Operons in nematodes have been known to be closely Figure 3. RNA-seq revisions of C. briggsae gene models. (A) An intron is confirmed if the predicted intron in the hybrid gene model...
  3. ...were yeast ( Saccharomyces cerevisiae ), a nematode worm ( Caenorhabditis elegans ), and a fruitfly ( Drosophila melanogaster ). The yeast , containing ∼12 million bp, is only 0.4% the length of the 3-billion-bp human , and the worm and fly s are ∼3.3% and 5.5% the length of the human , respectively...
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