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  1. ...-rays), chemical induction (ethyl methane sulphonate and 1,2:3,4-diepoxybutane), random DNA insertion (P-element, piggyBac, and T-DNA), and site-specific mutations (homologous recombination, integrase, RNAi, ZFN, TALEN, and CRISPR-Cas9) have been developed to generate large-scale mutant libraries in a few model...
  2. ...of the molecular structures involved in meiotic DNA break repair.ResultsOptimization of mutagenesis and validation of Dmc1 knockoutsWe performed mutagenesis on B6CASTF1 hybrid embryos, generated from parental mice of two subspecies with different Prdm9 alleles: a previously described genetically altered C57BL/6J...
  3. ...of indels that harbor mutations in DNA repair genes and strains with abundant males associated with him mutations. All the strains are available through the Caenorhabditis Genetics Center and all the sequence changes have been deposited in WormBase and are available through an interactive website...
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