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  1. ..., Moreno-Mayar JV, van Driem G, Gram Wilken U, Seguin-Orlando A, de la Fuente Castro C, et al. 2018. The prehistoric peopling of Southeast Asia. Science 361: 88–92. doi:10.1126/science.aat3628 ↵Morgan AP, Pardo-Manuel de Villena F. 2017. Sequence and structural diversity of mouse Y chromosomes. Mol Biol...
  2. ...of rapid tumor cell proliferation and/or metastasis driven by the overexpression of certain oncogenes (Péneau et al. 2022). As reported in Asia, as many as 40% of patients with HCC develop chronic hepatitis B (CHB) without underlying cirrhosis (Takano et al. 1995; Wong et al. 2013). Although no clear...
  3. ...Brown Norway strain (BN/SsNHsdMcw) was adopted as the first rat reference assembly, RGSC 3.1, in 2004 (Gibbs et al. 2004). The assembly was represented in haploid ploidy. This was followed by several revisions and updates (RGSC 3.4, 2004 Rnor_4, 2010, Rnor_5, 2012 Rnor_6.0 2014). The Celera assembly (Rn...
  4. ...by the ovary (Supplemental Table S4). In contrast to gene expression, the number of significantly associated AS and 3′APA events were relatively limited, with only two AS and six 3′APA events identified (Fig. 2A; Supplemental Table S4). Functional enrichment analysis revealed an overrepresentation...
  5. ...Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cisregulatory modules acting during vertebrate organogenesis Daniela M. Riley,1,7 Randa Elsayed,1,7 Mark D. Walsh,2,7 Simaran Johal,2 Ying Lin,3,4 Harry Walton,1 Till Bretschneider,5 Sascha Ott,1...
  6. ...1 Title 1 Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals 2 conserved gene alterations linked to Parkinson’s disease 3 Running title: Substantia nigra aging linked to Parkinson 4 Kangli Wang1, Weikun Xia1, Yingli Gu1, Songpeng Zu1, Qian Yang2, Maria Luisa Amaral1...
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  7. ...Cni-neib-1 in C. nigoni strains. Genes are color-coded as follows: Cni-neib-1 (red); conserved genes orthologous to those in other Caenorhabditis species including slc-25A18.2 (yellow) and pycr-4 (light green); histone genes (dark blue); a Cni-shls-1 paralog (brown); F55G1.1 (pink) and egas-4 (light...
  8. ...(Fig. 5A–G; Supplemental Fig. S10). Sequence analysis revealed a robust alternative start codon within the LTR7 sequence, altering the N-terminus of isoform 2 (Supplemental Fig. S11A), which was validated by mass spectrometry following overexpression (Fig. 5H; Supplemental Fig. S11B; Huang et al. 2024...
  9. ...; Hogan et al. 2017; Alizada et al. 2021), it was not known if specific cell types would be enriched for distinct TE subfamilies at NF-kB-bound regions. We looked for TE-associated RELA binding after TNF stimulation in: human umbilical vein endothelial cells (HUVECs; n = 12,442 [Brown et al. 2014...
  10. ...motif and coding sequences. METTL2A knockdown alters expression of S100A4 mRNA isoforms, which contains METTL2A-mediated m3C sites. Notably, many transcripts with METTL2A-mediated m3C sites are upregulated upon METTL2A knockdown. We reveal the transcriptome-wide presence of m3C sites in poly(A) RNA...
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