Searching journal content for articles similar to Price et al. 30 (1): 1.

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  1. Method: Bayesian estimation of cell type–specific gene expression with prior derived from single-cell data
    • Jiebiao Wang,
    • Kathryn Roeder,
    • and Bernie Devlin
    Genome Res. October 2021 31: 1807-1818; Published in Advance April 9, 2021, doi:10.1101/gr.268722.120
    ...RNA sequencing provides reliable data for gene expression at the tissue level. Single-cell RNA sequencing (scRNA-seq) deepens those analyses by evaluating gene expression at the cellular level. Both data types lend insights into disease etiology. With current technologies, scRNA-seq data are known...
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  2. Method: High-throughput single-cell functional elucidation of neurodevelopmental disease–associated genes reveals convergent mechanisms altering neuronal differentiation
    • Matthew A. Lalli,
    • Denis Avey,
    • Joseph D. Dougherty,
    • Jeffrey Milbrandt,
    • and Robi D. Mitra
    Genome Res. September 2020 30: 1317-1331; Published in Advance September 4, 2020, doi:10.1101/gr.262295.120
    ...studies in discovering thousands of disease-associated genes necessitates developing novel high-throughput functional genomics approaches to elucidate the molecular mechanisms of these genes. Here, we have coupled multiplexed repression of neurodevelopmental disease–associated genes to single...
  3. Research: Human-specific features of spatial gene expression and regulation in eight brain regions
    • Chuan Xu,
    • Qian Li,
    • Olga Efimova,
    • Liu He,
    • Shoji Tatsumoto,
    • Vita Stepanova,
    • Takao Oishi,
    • Toshifumi Udono,
    • Katsushi Yamaguchi,
    • Shuji Shigenobu,
    • Akiyoshi Kakita,
    • Hiroyuki Nawa,
    • Philipp Khaitovich,
    • and Yasuhiro Go
    Genome Res. August 2018 28: 1097-1110; Published in Advance June 13, 2018, doi:10.1101/gr.231357.117
    ...in the development and maintenance of the dopaminergic neuron system affected in Alzheimer's (Wruck et al. 2016) and Parkinson's diseases (Domanskyi et al. 2014). Mutations in the TEAD1 gene were shown to cause Aicardi syndrome, which is characterized by severe developmental brain defects (Schrauwen et al. 2015...
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  4. Research: Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver
    • Xia Yang,
    • Bin Zhang,
    • Cliona Molony,
    • Eugene Chudin,
    • Ke Hao,
    • Jun Zhu,
    • Andrea Gaedigk,
    • Christine Suver,
    • Hua Zhong,
    • J. Steven Leeder,
    • F. Peter Guengerich,
    • Stephen C. Strom,
    • Erin Schuetz,
    • Thomas H. Rushmore,
    • Roger G. Ulrich,
    • J. Greg Slatter,
    • Eric E. Schadt,
    • Andrew Kasarskis,
    • and Pek Yee Lum
    Genome Res. August 2010 20: 1020-1036; Published in Advance June 10, 2010, doi:10.1101/gr.103341.109
    ...to the response or adverse effects of various drugs used in the treatment of cancer, psychiatric disorders, and cardiovascular diseases (Anderson et al. 2003; van Schaik 2005; Vandel et al. 2007; Mega et al. 2009; Simon et al. 2009). In addition to genetic polymorphisms within P450 genes, regulatory mechanisms...
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