Searching journal content for articles similar to Prabhakar et al. 16 (7): 855.

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  1. .... S6A), which explains why negative genes were mistakenly predicted as positive genes. For TNs (Supplemental Fig. S6B), we observe a linear distribution of the four chromatin signals, with DNase and H3K27ac signals close to zero. Similarly, FNs also show a linear distribution of the chromatin signals...
  2. ...) and tissues (Fig. 3D–G). We find that in promoters the proportion of TEs in open chromatin decreases toward a transcription start site (TSS) and the gene body, probably reflecting increased purifying selection pressure (less tolerance for TE insertions) inside the gene body.Furthermore, we find that close...
  3. ...functional TE-derived cis-regulatory elements.Helitrons have been extensively reported on the promoter of other eukaryotic species (Gupta et al. 2005; Cultrone et al. 2007; Thomas et al. 2014; Huang et al. 2016), in which a few cases of embedded TFBSs were reported (Carareto et al. 2014; Batista et al. 2019...
  4. ...how the phylogenetic information in the multiassembly graph compares to what is known about species relationships from SNP studies of the Lake Malawi cichlid radiation (Malinsky et al. 2018). Overall, the pan graph closely reflected the expected interspecies relationships based on the prevailing...
  5. ...toward the mean as the sequences got shorter, HIGH and LOW sequences as short as 50 bp retained distinct activities (Wilcoxon test, P = 1.86 × 10−9) (Fig. 1E). This result suggests that most of the sequence features that are necessary for high activity of AP-1 sites reside close to the AP-1 core motifs...
  6. ...based on protein-coding genes in close proximity (significance of enrichment tests are reported in Supplemental Tables). Two background sets were used in GREAT analyses. The first, corresponding to the whole , was used to ensure sufficient sensitivity to detect small enrichments of relevant ontology...
  7. ...regulation.In addition to chromatin loops that involve enhancers, we also observed several promoter–promoter 3D interactions between genes that are upregulated by estrogen. This finding goes along with our observation that estrogen upregulated genes cluster in close proximity within the more than expected...
  8. ...SETDB1 through an intermediary cofactor, TRIM28, which is absent in zebrafish. However, two close relatives of TRIM28, namely, TRIM24 and TRIM33, are present in zebrafish and have been shown to silence endogenous retroviruses in mice (Boudinot et al. 2011; Margalit et al. 2020). Furthermore, structural...
  9. ...zebrafish and medaka pharyngula embryos morphologically and molecularly. We have examined both their transcriptomes and predictive epigenetic marks for conserved active enhancers during the phylotypic window. Whereas in closely related vertebrates, the high overall similarity masks the identification...
  10. ...using Oxford Nanopore Technologies (ONT) long-read sequencing (1.12 Gb total size and 9.3 Mb contig N50 after filtering; see Methods). We then combined a sex-specific coverage-based approach with synteny information from the W Chromosome of the closely related New Caledonian crow (Corvus moneduloides...
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