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  1. ...A Comprehensive Analysis of Allelic Methylation Status of CpG Islands on Human Chromosome 21q Yoichi Yamada 1 , 2 , Hidemi Watanabe 3 , 4 , Fumihito Miura 1 , 2 , Hidenobu Soejima 5 , Michiko Uchiyama 6 , Tsuyoshi Iwasaka 6...
  2. ...) Determinants of CpG islands: expression in early embryo and isochore structure . Genome Res. 11 : 1854 – 1860 . ↵ Rabinowicz, P.D. , Palmer, L.E. , May, B.P. , Hemann, M.T. , Lowe, S.W. , McCombie, W.R. , Martienssen, R.A. ( 2003 ) Genes and transposons are differentially methylated in plants...
  3. ...between exon and introns, the mCpG/ CpG level drops significantly in the intronic regions close to the splice sites. We then extended our analysis to look at the full human exome through ‘‘GC-content goggles’’ in the form of isochore maps (Costantini et al. 2006) and found the same patterns of epigenetic...
  4. ...description and parameters, see Methods). We first determined the CpG content of the promoters and divided them into CpG-rich and non-CpG subsets according to the overlap of the core promoter (#2;60 to +40 relative to the TSS), with CpG islands as predicted according to the method of Gardiner...
  5. ...of hypomethylated loci, usually but not exclusively at promoters and CpG islands. Intergenomic comparison found marked differences in cytosine methylation between spermatogenic and brain cells, identifying 223 new candidate tissue-specific differentially methylated regions (T-DMRs). Bisulfite pyrosequencing...
  6. ...., and Mouchiroud, D. 2001 . Determination of CpG islands: Expression in early embryo and isochore structure. Genome Res. 11 : 1854 -1860. ↵ Prestridge, D.S. 2000 . Computer software for eukaryotic promoter analysis. Review. Methods Mol. Biol. 130 : 265 -295. ↵ Scherf, M., Klingenhoff, A., and Werner, T. 2000...
  7. .... Genetics 156 : 297 – 304 . ↵ Nei M. , Kumar S. ( 2000 ) Molecular evolution and phylogenetics. ( Oxford University Press , New York, NY ). ↵ Ponger L. , Duret L. , Mouchiroud D. ( 2001 ) Determinants of CpG islands: Expression in early embryo and isochore structure. Genome Res. 11 : 1854 – 1860...
  8. ..., including the Xist gene. These comparisons have revealed conserved genes, both coding and noncoding, conserved CpG islands and, more surprisingly, conserved pseudogenes. The distribution of repeated elements, especially LINE repeats, in the mouse Xic region when compared to the rest of the genome does...
  9. .... ( 1933 ) On the problem of the most efficient tests of statistical hypotheses . Philos. Trans. R. Soc. Lond. Ser. A 231 : 289 – 337 . ↵ Ponger, L. , Duret, L. , Mouchiroud, D. ( 2001 ) Determinants of CpG islands: Expression in early embryo and isochore structure . Genome Res. 11 : 1854 – 1860...
  10. ...content of genes in the region ( Saccone et al. 1997 ). This notion is supported by the presence of eight putative CpG islands as well as by the analysis of EST/gene content (Fig. 1 ). Predicted genes that do not have significant matches to known genes are named t -complex expressed genes ( Tce...
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